Endoscopy enables minimally invasive procedures in many medical fields, such as urology. However, current endoscopes are normally cable-driven, which limits their dexterity and makes them hard to miniaturize. Indeed, current urological endoscopes have an outer diameter of about 3 mm and still only possess one bending degree-of-freedom. In this article, we report a novel wireless actuation mechanism that increases the dexterity and that permits the miniaturization of a urological endoscope. The novel actuator consists of thin active surfaces that can be readily attached to any device and are wirelessly powered by ultrasound. The surfaces consist of two-dimensional arrays of microbubbles, which oscillate under ultrasound excitation and thereby generate an acoustic streaming force. Bubbles of different sizes are addressed by their unique resonance frequency, thus multiple degrees-of-freedom can readily be incorporated. Two active miniaturized devices (with a side length of around 1 mm) are demonstrated: a miniaturized mechanical arm that realizes two degrees-of-freedom, and a flexible endoscope prototype equipped with a camera at the tip. With the flexible endoscope, an active endoscopic examination is successfully performed in a rabbit bladder. The results show the potential medical applicability of surface actuators wirelessly powered by ultrasound penetrating through biological tissues.
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http://dx.doi.org/10.1021/acsami.7b12755 | DOI Listing |
Sensors (Basel)
December 2024
CMEMS-UMinho, University of Minho, 4800-058 Guimarães, Portugal.
In biomedical research, telemetry is used to take automated physiological measurements wirelessly from animals, as it reduces their stress and allows recordings for large data collection over long periods. The ability to transmit high-throughput data from an in-body device (e.g.
View Article and Find Full Text PDFMater Today Bio
February 2025
Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, China.
ACS Appl Mater Interfaces
January 2025
School of Integrated Circuits and Electronics, Beijing Institute of Technology, Beijing 100081, China.
Portable sensor technologies are indispensable in personalized healthcare and environmental monitoring as they enable the continuous tracking of key analytes. Human sweat contains valuable physiological information, and previously developed noninvasive sweat-based sensors have effectively monitored single or multiple biomarkers. By successfully detecting biochemicals in sweat, portable sensors could also significantly broaden their application scope, encompassing non-biological fluids commonly encountered in daily life, such as mineral water.
View Article and Find Full Text PDFNat Commun
January 2025
Nanotechnology Center, School of Fashion and Textiles, The Hong Kong Polytechnic University, Hong Kong, 999077, China.
Wireless energy-responsive systems provide a foundational platform for powering and operating intelligent devices. However, current electronic systems relying on complex components limit their effective deployment in ambient environment and seamless integration of energy harvesting, storage, sensing, and communication. Here, we disclose a coupling effect of electromagnetic wave absorption and moist-enabled generation on carrier transportation and energy interaction regulated by ionic diode effect.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
School of Biomedical Engineering, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou, 510275, P. R. China.
Glioblastoma (GBM) is a lethal disease with a poor prognosis due to its strong infiltration, which makes it difficult to remove completely. In this study, an implantable, modulus-tunable, and ultrasound-powered MXene/PVA hydrogel-based tumor treatment device (UP-MPH-TTD), which generates specific electromagnetic alternating fields that disrupt the mitosis of cancer cells without adversely affecting normal neurons is developed. The MXene/PVA hydrogel is used to form a tumor treatment field due to its high biocompatibility, excellent flexibility, and high conductivity, which improves ultrasonic electrical conversion efficiency and significantly reduces the size of the equipment.
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