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- The AAOS guidelines indicate that early and delayed rehabilitation after arthroscopic rotator cuff repairs have similar healing outcomes, supported by "strong" evidence.
- A study analyzed randomized controlled trials (RCTs) with non-significant tendon re-tear rates to calculate the reverse fragility index (RFI) and reverse fragility quotient (RFQ), revealing that these studies are statistically weak.
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Single-cell sequencing delineates T-cell clonality and pathogenesis of the parapsoriasis disease group.
J Allergy Clin Immunol
September 2024
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:
Article Synopsis
- Mycosis fungoides (MF), a type of skin cancer, is often misdiagnosed early on because it resembles conditions like atopic dermatitis (AD), complicating the distinction from parapsoriasis, which can appear in small or large plaques.
- The study used single-cell RNA sequencing to analyze skin samples from patients showing both parapsoriasis and early-stage MF to better understand these diseases.
- Results showed that large-plaque lesions tended to have signs of early-stage MF while small-plaque lesions were more diverse and lacked cancerous characteristics, leading researchers to propose the term "polyclonal parapsoriasis en plaque" for these unique lesions.
Development of a Novel Assay for Direct Assessment of Selective Amylin Receptor Activation Reveals Novel Differences in Behavior of Selective and Nonselective Peptide Agonists.
Mol Pharmacol
April 2024
Drug Discovery Biology Theme (P.K., G.C., C.A.H., D.W., P.M.S.) and ARC Centre for Cryo-Electron Microscopy of Membrane Proteins (P.K., D.W., P.M.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Research & Early Development, Novo Nordisk, Novo Nordisk Park, Maaloev, Denmark (T.G., B.B.-G.)
Dual amylin and calcitonin receptor agonists (DACRAs) show promise as efficacious therapeutics for treatment of metabolic disease, including obesity. However, differences in efficacy in vivo have been observed for individual DACRAs, indicating that detailed understanding of the pharmacology of these agents across target receptors is required for rational drug development. To date, such understanding has been hampered by lack of direct, subtype-selective, functional assays for the amylin receptors (AMYRs).
View Article and Find Full Text PDFGlucagon-like peptide-1 and glucagon-like peptide-2 regulation during human liver regeneration.
Sci Rep
September 2023
Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Accumulating evidence suggests that metabolic demands of the regenerating liver are met via lipid metabolism and critical regulators of this process. As such, glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) critically affect hepatic regeneration in rodent models. The present study aimed to evaluate potential alterations and dynamics of circulating GLP-1 and GLP-2 in patients undergoing liver resections, focusing on post-hepatectomy liver failure (PHLF).
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