AI Article Synopsis
- A new dinuclear nickel complex has been created to facilitate the Mannich reaction between malonates and N-tosyl aryl imines.
- The catalyst works effectively at low concentrations (0.1-0.05 mol%) for larger scale reactions (5-50 mmol).
- The composition of the active catalyst was confirmed through various methods including control experiments, ESI-HRMS analysis, and computational DFT calculations.
Article Abstract
A novel dinuclear Ni complex has been developed for the direct Mannich reaction of malonates with N-tosyl aryl imines with a low catalyst loading (0.1-0.05 mol%) on a preparative scale (5-50 mmol). The structure of the active species was verified via control experiments, ESI-HRMS, and DFT calculations.
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| http://dx.doi.org/10.1039/c7cc06468c | DOI Listing |
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