AI Article Synopsis
- Breast cancer is the most common cancer among women worldwide, with triple-negative breast cancer (TNBC) being a challenging subtype due to the lack of specific targets for treatment.
- A study conducted in South India analyzed the clinical and pathological data from 237 TNBC patients diagnosed between 2010 and 2012, revealing median age as 45 years and that 58% were premenopausal.
- The 5-year disease-free and overall survival rates for non-metastatic TNBC were found to be 59% and 74%, but adding taxanes to anthracycline-based chemotherapy did not significantly improve these outcomes.
Article Abstract
Background: Breast cancer is the most common female cancer seen globally. Triple-negative breast cancer (TNBC) is a special subtype without any obvious target and optimum treatment remains challenging. The aim was to study the clinical, pathological profile and treatment outcome of TNBC patients.
Methods: This was a retrospective observational study of TNBC patients diagnosed from January 2010 to June 2012 at a tertiary cancer center in South India. Patient's clinical and pathological characteristics were studied. The 5-year estimate of survival for non-metastatic TNBC was done using the Kaplan-Meier method.
Results: Out of 804 patients of breast cancer, 237 were diagnosed as TNBC. The median age was 45 years and 58% were premenopausal. The 5-year disease-free survival (DFS) and overall survival (OS) for non-metastatic TNBC patients were 59% and 74%, respectively. The addition of a taxane to anthracycline-based regimen did not show a significant difference in DFS (P = 0.885) as well as OS (P = 0.856).
Conclusion: The role of adding taxanes to anthracycline-based chemotherapy in adjuvant setting for TNBC remains controversial and larger prospective studies are warranted.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650007 | PMC |
| http://dx.doi.org/10.14740/wjon1054w | DOI Listing |
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