Pemetrexed-Induced Interstitial Pneumonitis: A Case Study and Literature Review.

World J Oncol

Department of Medical Oncology, Flinders Medical Centre, Bedford Park, Adelaide, South Australia 5042, Australia.

Published: December 2014

Pemetrexed is a new-generation antifolate drug, now widely used in patients with non-small cell lung cancer (NSCLC). We report a case of pemetrexed-induced interstitial pneumonitis, and review the literature of eight previously reported cases. As pemetrexed is now a widely used chemotherapeutic agent, it is important to be aware of rare adverse events related to its administration.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649774PMC
http://dx.doi.org/10.14740/wjon845wDOI Listing

Publication Analysis

Top Keywords

pemetrexed-induced interstitial
8
interstitial pneumonitis
8
pneumonitis case
4
case study
4
study literature
4
literature review
4
review pemetrexed
4
pemetrexed new-generation
4
new-generation antifolate
4
antifolate drug
4

Similar Publications

Pemetrexed is a chemotherapeutic, antimetabolite agent that has been used in oncology to treat diseases such as metastatic non-small cell lung cancer and unresectable malignant pleural mesothelioma. Pemetrexed use may result in pseudocellulitis, which presents as poorly demarcated patches or plaques with erythema, edema, warmth, and tenderness. These lesions can present unilaterally or bilaterally on the lower extremities.

View Article and Find Full Text PDF
Article Synopsis
  • * A renal biopsy revealed damage likely caused by pemetrexed, leading to its withdrawal, but her kidney function continued to decline.
  • * A second biopsy indicated severe acute kidney inflammation from pembrolizumab, highlighting the need to be cautious about kidney toxicity when combining immunotherapies with chemotherapy.
View Article and Find Full Text PDF

Introduction: Sweet Syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory disease characterized by the sudden emergence of painful, edematous, and erythematous papules, plaques, or nodules on the skin, which usually fully responsive to systemic corticosteroids. Skin lesions are often accompanied by fever and leukocytosis. Here we present a case of Sweet Syndrome caused by pemetrexed in metastatic lung adenocarcinoma.

View Article and Find Full Text PDF

We herein report a 45-year-old woman with lung adenocarcinoma stage IV (cT4N3M1a). She was treated with pemetrexed (PEM) monotherapy following four cycles of first-line treatment with carboplatin, paclitaxel, and veliparib. After three cycles of PEM treatment, she presented with dyspnea, and chest computed tomography showed diffuse ground-glass attenuation (GGA), suggesting hypersensitivity pneumonia (HP).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!