Cytoreductive surgery with heated intraperitoneal chemotherapy (CRS/HIPEC) remains a controversial treatment for malignant disease of the peritoneal cavity. We review the scientific principles underscoring the rationale for CRS/HIPEC, recent innovations and ongoing controversies. Lack of level 1 data limits the understanding of the true benefit of CRS/HIPEC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649776 | PMC |
| http://dx.doi.org/10.4021/wjon660w | DOI Listing |
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