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http://dx.doi.org/10.2471/BLT.17.195453 | DOI Listing |
Microorganisms
January 2025
Department of Food Science and Biotechnology, College of Bionano Technology, Gachon University, Seongnam 13120, Republic of Korea.
Shiga toxin-producing (STEC) infections have increased in humans, animals, and the food industry, with ready-to-eat (RTE) food products being particularly susceptible to contamination. The prevalence of multidrug-resistant strains has rendered the current control strategies insufficient to effectively control STEC infections. Herein, we characterized the newly isolated STEC phage vB_ESM-pEJ01, a polyvalent phage capable of infecting and species, and assessed its efficacy in reducing STEC in vitro and food matrices.
View Article and Find Full Text PDFSmall
January 2025
Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
A polyacrylamide gel method has been used to synthesize a variety of polyvalent-transition-metal-doped Ni position of high entropy spinel oxides (NiZnMgCuCo)AlO-800 °C (A) on the basis of NiAlO, and the catalytic activity of A is studied under the synergistic action of peroxymonosulfate (PMS) activation and simulated sunlight. The A containing polyvalent transition metals (Ni, Cu, and Co) can effectively activate PMS and efficiently degrade levofloxacin (LEV) and tetracycline hydrochloride (TCH) under simulated sunlight irradiation. After 90 min of light exposure, the degradation percentages of LEV (50 mg L) and TCH (100 mg L) degrade by the A/PMS/vis system reach 87.
View Article and Find Full Text PDFVirol J
January 2025
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361102, PR China.
Coxsackievirus A6 (CVA6) has emerged as a major pathogen causing hand, foot and mouth disease (HFMD) outbreaks worldwide. The CVA6 epidemic poses a new challenge in HFMD control since there is currently no vaccine available against CVA6 infections. The Vero cell line has been widely used in vaccine production, particularly in the preparation of viral vaccines, including poliovirus vaccines and EV71 vaccines.
View Article and Find Full Text PDFTheranostics
January 2025
Departments of Radiology, Washington University in St. Louis, MO 63110, USA.
Cancer remains a leading cause of mortality, with aggressive, treatment-resistant tumors posing significant challenges. Current combination therapies and imaging approaches often fail due to disparate pharmacokinetics and difficulties correlating drug delivery with therapeutic response. In this study, we developed radionuclide-activatable theranostic nanoparticles (NPs) comprising folate receptor-targeted bimetallic organo-nanoparticles (Gd-Ti-FA-TA NPs).
View Article and Find Full Text PDFEpilepsia
January 2025
Unit of Innovative Treatments, Hospital de Pediatría JP Garrahan, Buenos Aires, Argentina.
Objective: Identifying factors influencing cannabidiol (CBD) exposure can optimize treatment efficacy and safety. We aimed to describe the population pharmacokinetics of CBD in children with drug-resistant developmental and epileptic encephalopathies (DEEs) and assess the influence of environmental, pharmacological, and clinical characteristics on CBD systemic exposure.
Methods: Data from two pharmacokinetic studies of patients aged 2-18 years with DEEs were included (N = 48 patients).
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