AI Article Synopsis
- Two new dimeric compounds, diselaginellins A and B, were isolated from Selaginella pulvinata, alongside two known derivatives.
- Their structures were determined using advanced NMR and high-resolution ESIMS techniques.
- Diselaginellin B demonstrated the ability to induce apoptosis and reduce metastasis in liver cancer cells, with its effects linked to the modulation of genes involved in metabolism and angiogenesis.
Article Abstract
Two new unusual dimeric selaginellins, diselaginellins A and B (1 and 2), along with two known derivatives, selaginellin (3) and selaginellin B (4), were isolated from Selaginella pulvinata. Their structures were elucidated by extensive NMR and high-resolution ESIMS data analysis. Compound 2 displayed apoptosis-inducing and antimetastatic activities against the human hepatocellular carcinoma cell line SMMC-7721. A microarray analysis revealed that genes related to metabolism, angiogenesis, and metastasis were altered by 2. The up- and down-regulation of the mRNA levels of related genes was confirmed by RT-qPCR. Metabolism modulation and metastasis inhibition might be the mechanisms of the antitumor properties of diselaginellin B (2).
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| http://dx.doi.org/10.1021/acs.jnatprod.7b00404 | DOI Listing |
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