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Superoxide dismutase content in sperm correlates with motility recovery after thawing of cryopreserved human spermatozoa.
Fertil Steril
February 2012
Instituto de Biologia y Medicina Experimental, CONICET, Buenos Aires, Argentina.
Objective: To investigate the correlation between sperm superoxide dismutase (SOD) content and motility recovery after thawing of cryopreserved human sperm, based on the rationale that this antioxidant enzyme provides protection against reactive oxygen species-induced damage during cryopreservation.
Design: Prospective study.
Setting: Private infertility institute and university-based research laboratory.
Acrosomal exocytosis of mouse sperm progresses in a consistent direction in response to zona pellucida.
J Cell Physiol
September 2009
Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women's Health, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6160, USA.
Sperm acrosomal exocytosis is essential for successful fertilization, and the zona pellucida (ZP) has been classically considered as the primary initiator in vivo. At present, following what is referred to as primary binding of the sperm to the ZP, the acrosome reaction paradigm posits that the outer acrosomal membrane and plasma membrane fuse at random points, releasing the contents of the acrosome. It is then assumed that the inner acrosomal membrane mediates secondary binding of the sperm to the ZP.
View Article and Find Full Text PDFEffect of thawing temperature on the motility recovery of cryopreserved human spermatozoa.
Fertil Steril
February 2010
Laboratorio de Estudios en Reproducción, Buenos Aires, Argentina.
Objective: To investigate the effects of thawing temperature on sperm function after cryopreservation. The technical aspects of sperm cryopreservation have significantly improved over the last few decades. However, a standard protocol designed to optimize sperm motility recovery after thawing has not yet been established.
View Article and Find Full Text PDFMammalian sperm metabolism: oxygen and sugar, friend and foe.
Int J Dev Biol
December 2008
Center for Research on Reproduction and Women's Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6142, USA.
Mammalian spermatozoa expend energy, generated as intracellular ATP, largely on motility. If the sperm cell cannot swim by use of its flagellar motion, it cannot fertilize the egg. Studies of the means by which this energy is generated span a period of six decades.
View Article and Find Full Text PDFBovine sperm capacitation: assessment of phosphodiesterase activity and intracellular alkalinization on capacitation-associated protein tyrosine phosphorylation.
Mol Reprod Dev
April 2004
Center for Research on Reproduction and Women's Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA.
Mammalian sperm capacitation is the obligatory maturational process leading to the development of the fertilization-competent state. Heparin is known to be a unique species-specific inducer of bovine sperm capacitation in vitro and glucose a unique inhibitor of this induction. Heparin-induced capacitation of bovine sperm has been shown to correlate with protein kinase A (PKA)-dependent protein tyrosine phosphorylation driven by an increase in intracellular cAMP.
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