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Targeting CEACAM5-positive solid tumors using NILK-2401, a novel CEACAM5xCD47 κλ bispecific antibody.
Front Immunol
May 2024
LamKap Bio beta AG, Pfäffikon SZ, Switzerland.
Background: Blocking the CD47 "don't eat me"-signal on tumor cells with monoclonal antibodies or fusion proteins has shown limited clinical activity in hematologic malignancies and solid tumors thus far. Main side effects are associated with non-tumor targeted binding to CD47 particularly on blood cells.
Methods: We present here the generation and preclinical development of NILK-2401, a CEACAM5×CD47 bispecific antibody (BsAb) composed of a common heavy chain and two different light chains, one kappa and one lambda, determining specificity (so-called κλ body format).
Erythrophagocytosis by Blasts and Numerous Cytoplasmic Granules in a Child with De Novo T-lymphoblastic Leukemia.
Turk J Haematol
December 2023
The District People’s Hospital of Zhangqiu, Department of Clinical Laboratory, Jinan, China
Infrequent erythrophagocytosis by leukemic blasts in de novo T-lymphoblastic leukemia with SIL-TAL1: A rare pediatric case.
Pediatr Blood Cancer
October 2023
Department of Clinical Laboratory, The Fifth People's Hospital of Jinan, Jinan, Shandong, China.
Unexplored Roles of Erythrocytes in Atherothrombotic Stroke.
Neurol Int
January 2023
Department of Neurology, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Stroke constitutes the second highest cause of morbidity and mortality worldwide while also impacting the world economy, triggering substantial financial burden in national health systems. High levels of blood glucose, homocysteine, and cholesterol are causative factors for atherothrombosis. These molecules induce erythrocyte dysfunction, which can culminate in atherosclerosis, thrombosis, thrombus stabilization, and post-stroke hypoxia.
View Article and Find Full Text PDFT-cell lymphoma-associated hemophagocytic syndrome in an American Pit Bull Terrier.
J Vet Diagn Invest
March 2022
Departments of Pathobiology, Tuskegee University College of Veterinary Medicine, Tuskegee Institute, Tuskegee, AL, USA.
A 3-y-old, intact female, American Pit Bull Terrier was presented because of acute onset of anorexia and a large subcutaneous submandibular mass that had been present for 3 wk. The submandibular mass, 2 engorged black-legged ticks on the dorsum of the neck, pyrexia, and icterus were seen on physical examination. Abnormal laboratory test results included a positive antibody test, severe thrombocytopenia, mild nonregenerative anemia, hyperbilirubinemia, and elevated liver enzyme activities.
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