Leptospirosis is an emerging bacterial zoonosis that is endemic but underrecognized throughout the tropics. Through prospective surveillance for acute febrile illness (AFI) among patients who presented to the emergency department of a hospital located in an urban region of Puerto Rico, four patients with laboratory-confirmed leptospirosis were identified. All patients had signs and symptoms of AFI, including fever, headache, and dehydration. Three patients had leukocytosis with thrombocytopenia and were admitted to the hospital. One hospitalized patient presented with jaundice, icteric sclera, and hematuria and developed rhabdomyolysis, whereas another patient with pulmonary edema was admitted to the intensive care unit. Microscopic agglutination titers among the four patients were highest against serogroups Icterohaemorrhagiae (serovar Mankarso), Australis (serovar Bratislava), Bataviae (serovar Bataviae), and Canicola (serovar Canicola). These case reports demonstrate that infection with these apparently uncommon serogroups can result in illness ranging from mild to life-threatening.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928731 | PMC |
| http://dx.doi.org/10.4269/ajtmh.17-0538 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Streptococcus pneumoniae infection is considered an uncommon cause of arthritis in adults. To determine the clinical and microbiological characteristics of pneumococcal septic arthritis, we retrospectively studied a large series of cases among adult patients during the 2010-2018 conjugate vaccine era in France. We identified 110 patients (56 women, 54 men; mean age 65 years), and cases included 82 native joint infections and 28 prosthetic joint infections.
View Article and Find Full Text PDFGlobal Epidemiology of Meningococcal Disease-Causing Serogroups Before and After the COVID-19 Pandemic: A Narrative Review.
Infect Dis Ther
December 2024
Pfizer Global Medical Affairs, Vaccines and Antivirals, Pfizer Inc, Collegeville, PA, USA.
Article Synopsis
- Invasive meningococcal disease (IMD) is mainly caused by five Neisseria meningitidis serogroups (A/B/C/W/Y), leading to high morbidity and mortality, especially in certain age groups.
- Polysaccharide conjugate vaccines can produce strong immune responses and lower disease transmission, highlighting the importance of tailored vaccination programs based on local prevalence and epidemiology.
- Recent trends show that while serogroup A has declined due to vaccination, other serogroups like B, C, W, and Y have varied impacts, and IMD has resurged during the pandemic, particularly affecting unvaccinated individuals.
Invasive meningococcal disease (IMD) is a severe illness that can have devastating effects; outbreaks are uncommon in the United States. Vaccination is the preferred control measure for IMD outbreaks when a defined population at risk (e.g.
View Article and Find Full Text PDFUnderstanding the Sequelae of Invasive Meningococcal Disease in the United States.
Infect Dis Ther
November 2024
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Invasive meningococcal disease (IMD) is an uncommon but serious and potentially fatal condition that can result in reduced life expectancy and a broad spectrum of sequelae, many of which may be lifelong and devastating for those who survive the acute disease period. In the United States of America (USA), vaccination is available against the five meningococcal serogroups (A, B, C, W, and Y), but meningococcal vaccination rates among healthy USA adolescents and individuals at high risk because of medical conditions are low, rendering them vulnerable to IMD and its sequelae. Despite the severity of the disease, the clinical impact and rates of IMD sequelae in the USA are poorly understood, as USA-specific data are limited, and the methodology of existing research is heterogenous.
View Article and Find Full Text PDFFunctional Identification and Genetic Analysis of O-Antigen Gene Clusters of Food-Borne Pathogen O:10 and Other Uncommon Serotypes, Further Revealing Their Virulence Profiles.
J Microbiol Biotechnol
August 2024
TEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, P.R. China.
is a globally distributed food-borne gastrointestinal pathogen. The O-antigen variation-determined serotype is an important characteristic of , allowing intraspecies classification for diagnosis and epidemiology purposes. Among the 11 serotypes associated with human yersiniosis, O:3, O:5,27, O:8, and O:9 are the most prevalent, and their O-antigen gene clusters have been well defined.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!