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Fungal Osteomyelitis of a Diabetic Foot Infection Caused by Trichosporon asahii: A Case Report.
Adv Skin Wound Care
January 2025
At Baylor College of Medicine, Houston, Texas, United States, Livia Frost, BS, is Medical Student, School of Medicine; Ya Xu, MD, PhD, is Assistant Professor, Department of Pathology & Immunology; and Yuriko Fukuta, MD, PhD, CWSP, is Assistant Professor, Department of Medicine, Section of Infectious Diseases.
Diabetic foot bacterial osteomyelitis is a serious infection that can lead to major amputations. However, fungal osteomyelitis in a diabetic foot ulcer is uncommon and has been underrecognized. It typically occurs in patients with underlying immunocompromised status and is associated with poor outcomes.
View Article and Find Full Text PDFOsteoarticular tuberculosis: imaging findings in pediatric patients.
Pediatr Radiol
November 2024
Hospital de Niños Exequiel González Cortes, Santiago, Chile.
Osteoarticular tuberculosis (TB) is an uncommon form of extrapulmonary TB that has the potential to damage joints and bones, generating long-term impairment. Mainly, the initial diagnosis of osteoarticular TB relies on clinical findings and imaging. When required, imaging can aim for less invasive tissue or fluid sampling for pathology, microbiology, and molecular biology analysis.
View Article and Find Full Text PDFFungal Malignant Otitis Externa: A Systematic Review.
Cureus
October 2024
2nd ENT Department, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Article Synopsis
- Malignant otitis externa (MOE) is a serious condition often linked to fungi, especially in people with weakened immune systems, prompting a review of fungal cases (FMOE) among patients.
- The study analyzed 10 articles covering 197 patients, mostly older adults (average age 65.9 years), highlighting that a significant number (78.7%) had conditions like diabetes or cancer.
- Most patients received conservative treatment focusing on antifungals like itraconazole, with a notable 4% mortality rate attributed to factors such as late diagnosis and cranial nerve issues, suggesting that early antifungal treatment could enhance patient outcomes.
Microbial profile of diabetic foot osteomyelitis from the northwest of England.
Clin Diabetes Endocrinol
November 2024
University of Manchester, Manchester, UK.
Article Synopsis
- Osteomyelitis in diabetic foot patients is complicated by polymicrobial infections, which have high rates of persistence and recurrence, prompting this study to evaluate microbiological profiles and resistance patterns.
- A retrospective review of 105 patients showed that only 42% achieved infection eradication, while 18% experienced persistence and 40% faced late recurrence, with 72% of cases exhibiting polymicrobial growth, primarily from gram-positive bacteria.
- Notably, Staphylococcus aureus was the most prevalent pathogen, and both gram-positive and gram-negative bacteria demonstrated significant antibiotic resistance, highlighting challenges in treatment strategies for persistent infections.
A Sr@Ag-based spatiotemporal and step-release scaffold against chronic osteomyelitis, fabricated by coaxial 3D-printing.
Biomaterials
March 2025
Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, People's Republic of China; Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, People's Republic of China. Electronic address:
Chronic osteomyelitis (OM) represents a severe and persistent infectious bone disease. Effective treatment requires controlled anti-inflammatory releases and bone regeneration across disease phases. A Sr@Ag-based scaffold was successfully printed, featuring micron-scale coaxial fibers containing Ag-doped hydroxyapatite (HA) in the outer layer of PLLA and Sr-doped HA in the inner layer of PLLA, facilitating the spatiotemporal and sequential release of Ag and Sr ions during OM treatment.
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