A five years' experience of the care by general surgeons of patients with severe head injuries in a general surgical unit with inferior facilities was retrospectively reviewed. It was concluded that the mortality compared favourably with that in similar patients managed by neurosurgeons in specialized centres. The still inadequate understanding of primary diffuse brain damage in head injuries is suggested as the cause for this lack of significant improvement in results over the years. Certain guide-lines, however, exist to allow prediction of the eventual outcome in these patients.
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http://dx.doi.org/10.1111/j.1445-2197.1979.tb05837.x | DOI Listing |
J Brachial Plex Peripher Nerve Inj
January 2025
School of Health Sciences, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. In response to injury within the central nervous system, GABA promotes cortical plasticity and represents a potential pharmacological target to improve functional recovery. However, it is unclear how GABA changes in the brain after traumatic brachial plexus injuries (tBPIs) which represents the rationale for this pilot study.
View Article and Find Full Text PDFStem Cell Res Ther
January 2025
Department of Neurosurgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, 100853, China.
Background: Closed head injury (CHI) provokes a prominent neuroinflammation that may lead to long-term health consequences. Microglia plays pivotal and complex roles in neuroinflammation-mediated neuronal insult and repair following CHI. We previously reported that induced neural stem cells (iNSCs) can block the effects of CXCL12/CXCR4 signaling on NF-κB activation in activated microglia by CXCR4 overexpression.
View Article and Find Full Text PDFBMC Public Health
January 2025
Sefako Makgatho University, Ground Floor, Clin Path Building, Room No. 37. Garankuwa, Pretoria, South Africa.
Background: Femicides, defined as the gender-based killing of women, are a pressing public health issue worldwide, with South Africa experiencing some of the highest rates globally. This study focuses on the North-west region of Tshwane, particularly the Garankuwa area, aiming to address gaps in understanding the epidemiology, demographics, circumstances, and pathology associated with femicides. The Garankuwa mortuary serves as the primary site for this investigation, providing a detailed analysis over a ten-year period, shedding light on contributing risk factors in the context of systemic gender inequality.
View Article and Find Full Text PDFSci Rep
January 2025
Cardiothoracic Surgery and Transplant Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
The choice between total thyroidectomy (TT) and subtotal thyroidectomy (STT) can affect postoperative complications and long-term outcomes in these patients. This study aimed to investigate postoperative complications and long-term outcomes in patients who underwent TT and STT. This retrospective study investigated 1.
View Article and Find Full Text PDFInt Ophthalmol
January 2025
Department of Ophthalmology, Rutgers New Jersey Medical School, Institute of Ophthalmology and Visual Science, Newark, NJ, USA.
Purpose: The purpose of this study is to analyze the trends and characteristics of ocular trauma research published from 2000 to 2022 to delineate the trajectory of the field's research, provide information about the network of key contributors, and help determine future research strategies and direction.
Methods: Web of Science was queried for published works using a series of keywords relating to ocular trauma: "globe rupture", "ruptured globe", "globe injury", "ocular trauma", "intraocular foreign body", "eye trauma", "eye injury", and "traumatic endophthalmitis". All article information was compiled using the VOSviewer software.
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