AI Article Synopsis
- Complex networks are useful for modeling biological systems, with a focus on the concept of accessibility to classify nodes as either border or center.
- Recent research explores how the position of nodes in these networks affects their functional and structural properties.
- In this study, the authors analyze Protein-Protein Interaction networks in four Mycoplasma organisms, finding that a protein's "borderness" relates to its spatial organization and specific molecular functions.
Article Abstract
Complex networks have been widely used to model biological systems. The concept of accessibility has been proposed recently as a means to organize the nodes of complex networks as belonging to its border or center. Such an approach paves the way to investigating how the functional and structural properties of nodes vary with their respective position in the networks. In this work, we approach such a problem in a biological context applying border detection to Protein-Protein Interaction networks from four organisms of the Mycoplasma genus. We found evidence that the borderness of proteins bears a relation with their spatial organization and molecular function specificity.
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| http://dx.doi.org/10.1039/c7ib00161d | DOI Listing |
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