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Production and Its Anti-hyperglycemic Effects of γ-Aminobutyric Acid from the Wild Yeast Strain UL6-1 and 402-JB-1. | LitMetric

Production and Its Anti-hyperglycemic Effects of γ-Aminobutyric Acid from the Wild Yeast Strain UL6-1 and 402-JB-1.

Mycobiology

Department of Biomedicinal Science and Biotechnology, Paichai University, Daejeon 35345, Korea.

Published: September 2017

AI Article Synopsis

Article Abstract

This study was done to produce γ-aminobutyric acid (GABA) from wild yeast as well as investigate its anti-hyperglycemic effects. Among ten GABA-producing yeast strains, UL6-1 and 402-JB-1 produced high GABA concentration of 134.4 µg/mL and 179.2 µg/mL, respectively. UL6-1 showed a maximum GABA yield of 136.5 µg/mL and 200.8 µg/mL from 402-JB-1 when they were cultured for 30 hr at 30℃ in yeast extract-peptone-dextrose medium. The cell-free extract from UL6-1 and 402-JB-1 showed very high anti-hyperglycemic α-glucosidase inhibitory activity of 72.3% and 69.9%, respectively. Additionally, their cell-free extract-containing GABA showed the anti-hyperglycemic effect in streptozotocin-induced diabetic Sprague-Dawley rats.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673516PMC
http://dx.doi.org/10.5941/MYCO.2017.45.3.199DOI Listing

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