Background: Endobronchial valve (EBV) placement is an established lung volume reduction procedure aiming to improve lung function and exercise capacity in patients with severe emphysema. As EBVs consist of silicone and nitinol (a metal alloy of nickel and titanium), there are concerns that nickel ions might be released and could have a clinical impact in patients with a contact allergy to nickel. Based on a case with hypersensitivity pneumonitis (HP) after treatment with EBVs, we aimed to evaluate the in vitro nickel release from EBVs using inductively coupled plasma mass spectrometry (ICP-MS) and scanning electron microscopy (SEM).
Methods: Six EBVs were immersed in artificial saliva for a period of 7 days. At 24-h intervals, the nickel ion concentration was measured using ICP-MS.
Results: There was evidence of a significant nickel release from EBV during the first 48 h, which is possibly due to an incomplete silicone layer detected by SEM. The concentration of released nickel was below the toxic limit.
Conclusions: To the best of our knowledge, we report the first case of HP after EBV treatment. Our finding of in vitro release of nickel ions from EBVs may contribute to the current understanding on hypersensitivity reactions after nitinol implants in patients with nickel contact allergy. However, it did not confirm a causative relationship.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1159/000481986 | DOI Listing |
Sci Rep
January 2025
Shanxi Provincial Geological Prospecting Bureau, Taiyuan, 030001, China.
In China, a significant amount of coal fly ash is stored or used for landfill reclamation. The contaminants in coal fly ash (CFA) leachate can cause regional soil and groundwater contamination during long-term storage. This paper focuses on a coal gangue comprehensive utilisation power plant in Fenyang City, Shanxi Province, China, where the leaching characteristics of CFA were investigated by leaching tests.
View Article and Find Full Text PDFNano Lett
January 2025
College of Chemistry and Materials Science, Hebei University, Baoding 071002, Hebei, P. R. China.
Ultrahigh nickel cathode materials are widely utilized due to their outstanding energy and power densities. However, the presence of cobalt can cause significant lattice distortion during charge and discharge cycles, leading to the loss of active lithium, the formation of lattice cracks, and the emergence of a rock salt phase that hinders lithium-ion transport. Herein, we developed a novel cobalt-free, aluminum-doped cathode material, LiNiMnAlO (NMA), which effectively delays the harmful H2-H3 phase transition, reduces lattice distortion, alleviates stress release, and significantly enhances structural stability.
View Article and Find Full Text PDFSmall
January 2025
MEET, Battery Research Center, University of Muenster, 48149, Muenster, Germany.
Rechargeable lithium-ion batteries (LIBs) are critical for enabling sustainable energy storage. The capacity of cathode materials is a major limiting factor in the LIB performance, and doping has emerged as an effective strategy for enhancing the electrochemical properties of nickel-rich layered oxides such as NCM811. In this study, boron is homogeneously incorporated into the tetrahedral site of NCM811 through co-precipitation, leading to an inductive effect on transition metal (TM)-O-B bonds that delayed structural collapse and reduced oxygen release.
View Article and Find Full Text PDFPlant Physiol Biochem
October 2024
International Research Centre for Environmental Membrane Biology and Department of Horticulture, Foshan University, Foshan, China; V.F. Kuprevich Institute of Experimental Botany, National Academy of Sciences of Belarus, Minsk, Belarus. Electronic address:
Nickel is both an important nutrient and an ecotoxicant for plants. Organic ligands, such as L-histidine (His), play a key role in Ni detoxification. Here, we show that His (added together with 0.
View Article and Find Full Text PDFJ Pharm Sci
January 2025
Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:
By inducing apoptosis, promoting differentiation and reducing the migration of cancer cells, arsenic has a higher therapeutic effect and lower risk of recurrence and metastasis than conventional anticancer drugs. However, the low bioavailability and adverse side effects of arsenic hinder its application in hepatocellular carcinoma (HCC). Therefore, a M1 macrophage membrane-coated nickel-arsenic/polydopamine nanocomplex (NiAsOx@P@M) was constructed to enhance the combined antitumor effects of chemotherapy and immunotherapy.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!