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Phenytoin-induced Excessive Sedation During Awake Craniotomy: An Unusual Observation.
J Neurosurg Anesthesiol
January 2019
Department of Neuroanaesthesiology and Critical Care, All India Institute of Medical Sciences, New Delhi, India.
Phenytoin-induced Stevens-Johnson syndrome with myocarditis: a rare case report.
Int Med Case Rep J
July 2017
Department of Medicine, Belgaum Institute of Medical Sciences, Belgaum, India.
Stevens-Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction caused by excessive necrosis and detachment of the epidermis. It is commonly drug induced and phenytoin is a common precipitant. Phenytoin, an antiepileptic drug, is also known to cause myocarditis.
View Article and Find Full Text PDFA case of delayed eruption of the primary dentition secondary to phenytoin therapy in a 4-year-old child is reported. The patient had been on phenytoin therapy since the first months of life. Radiographs revealed that alveolar but not gingival emergence had occurred.
View Article and Find Full Text PDFQuantitative histopathologic assessment of developing phenytoin-induced gingival overgrowth in the cat.
J Clin Periodontol
September 1982
Phenytoin (Dilantin) induces gingival overgrowth characterized by an accumulation of connective tissue The cell-to-matrix ratio in the mature lesion is normal, yet there must be more fibroblasts per oral cavity if there is excessive tissue mass. Using a mongrel cat model system, we studied the early, developing phenytoin-induced lesion by quantitating fibroblasts per unit of tissue in papilla biopsies collected over a 3-month period of daily drug administration. At 6 and 8 weeks, the number of fibroblasts per unit of tissue increased dramatically.
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