Secondary C(sp )-H arylations were accomplished by palladium catalysis with triazoles as peptide bond isosteres. The unique power of this approach is highlighted by the possibility of achieving secondary C(sp )-H functionalizations on terminal peptides as well as the unprecedented positional-selective C(sp )-H functionalization of internal peptide positions, setting the stage for modular peptide late-stage diversification.
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| http://dx.doi.org/10.1002/anie.201710136 | DOI Listing |
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