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Progress in Transdifferentiation of Autologous Alternative Cell Sources into Corneal Epithelial Cells.
Stem Cell Rev Rep
October 2024
Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Corneal limbal epithelial stem cells (LESCs) play a crucial role in corneal epithelium regeneration. Severe damage to these cells can result in limbal stem cell deficiency (LSCD), characterized by repeated corneal conjunctivalization, leading to corneal turbidity and scar formation. Restoring functional LESCs and their ecological location are essential for treating LSCD.
View Article and Find Full Text PDFOcular Involvement in Patients with Infantile Nephropathic Cystinosis.
Turk J Ophthalmol
August 2024
Selçuk University Faculty of Medicine, Department of Ophthalmology, Konya, Türkiye.
Cystinosis is a rare autosomal recessive lysosomal storage disease associated with high mortality and morbidity rates. The most distinctive ocular manifestations of cystinosis are photophobia, tearing, and blurred vision. Herein, we assessed the ocular involvement of four patients from two families diagnosed with infantile nephropathic cystinosis using optical coherence tomography (OCT) and confocal microscopy (IVCM).
View Article and Find Full Text PDFDecoding cellular plasticity and niche regulation of limbal stem cells during corneal wound healing.
Stem Cell Res Ther
July 2024
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao, China.
Background: Dysfunction or deficiency of corneal epithelium results in vision impairment or blindness in severe cases. The rapid and effective regeneration of corneal epithelial cells relies on the limbal stem cells (LSCs). However, the molecular and functional responses of LSCs and their niche cells to injury remain elusive.
View Article and Find Full Text PDFPseudofilariasis, a Presenting Sign of Alkaptonuria.
Cornea
December 2024
Ophthalmic Consultants of Long Island, Rockville Centre, NY.
Purpose: To report the association of Pseudofilariasis as a presenting sign of Alkaptonuria.
Method: Case Report.
Results: A 49-year-old Indian man was referred because of wormlike objects in his left conjunctiva.
Identification of LRRC46 as a novel candidate gene for high myopia.
Sci China Life Sci
September 2024
Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
High myopia (HM) is the primary cause of blindness, with the microstructural organization and composition of collagenous fibers in the cornea and sclera playing a crucial role in the biomechanical behavior of these tissues. In a previously reported myopic linkage region, MYP5 (17q21-22), a potential candidate gene, LRRC46 (c.C235T, p.
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