The extent of metastatic spread and the life span depend on the level of nonspecific resistance of the body of patients with osteogenic sarcoma. Chemoradiation therapy reduces antitumoral resistance of patients, and the use of local UHF hyperthermia prevents this negative effect of complex treatment.
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Acta Biomater
December 2023
School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107, China. Electronic address:
Ultra-high-field (UHF) MRI has shown great advantages over low-field magnetic resonance imaging (MRI). Despite being the most commonly used MRI contrast agents, gadolinium chelates perform poorly in high magnetic fields, which significantly weakens their T intensity. In comparison, the rare element Holmium (Ho)-based nanoparticles (NPs) have demonstrated great potential as T-weighted MRI contrast agents in UHF MRI due to their extremely short electron relaxation times (∼ 10s).
View Article and Find Full Text PDFMethods Mol Biol
February 2023
Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Marburg, Germany.
Liposome-mediated anticancer drug delivery has the advantage of limiting the massive cytotoxicity of chemotherapeutic agents. Doxorubicin (DOX) PEG-liposomal does however have a slow-release rate that hinders its therapeutic efficacy. In this study, an integrated therapeutic system based on magnetic thermosensitive liposomes was designed.
View Article and Find Full Text PDFMater Sci Eng C Mater Biol Appl
October 2020
Department of Pharmaceutics and Biopharmaceutics, University of Marburg, 35037 Marburg, Germany. Electronic address:
To limit the massive cytotoxicity of chemotherapeutic agents, it is desirable to establish an appropriate subtle blend of formulation design based on a dual-responsive strategy. In this study, a combined therapeutic platform based on magnetic thermosensitive liposomes (Lip) was developed. The incorporation of chelated-gadolinium imparted magnetic properties to thermosensitive liposomes (Lip).
View Article and Find Full Text PDFMagn Reson Med
January 2018
Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany.
Purpose: To examine radiofrequency-induced tissue heating around intracranial aneurysm clips during a 7 Tesla (T) head MR examination.
Methods: Radiofrequency (RF), temperature simulations, and RF measurements were employed to investigate the effects of polarization and clip length on the electric field (E-field) and temperature. Heating in body models was studied using both a conservative approach and realistic exposure scenarios.
The report discusses the results of an evaluation of the effectiveness of combined radiotherapy in 1,192 cases of head and neck tumors divided into 4 groups: distant radiotherapy in standard fractions of 1.8-2.3 Gy, 5 times a week, TTD of 60 Gy (group 1 - 486 40.
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