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Dihydropyrimidine enzyme activity and its effect on chemotherapy toxicity: importance of genetic testing.
Cancer Chemother Pharmacol
January 2025
Markey Cancer Center, University of Kentucky, Lexington, KY, USA.
Purpose: Patients with partial or complete DPD deficiency have decreased capacity to degrade fluorouracil and are at risk of developing toxicity, which can be even life-threatening.
Case: A 43-year-old man with moderately differentiated rectal adenocarcinoma on capecitabine presented to the emergency department with complaints of nausea, vomiting, diarrhea, weakness, and lower abdominal pain for several days. Laboratory findings include grade 4 neutropenia (ANC 10) and thrombocytopenia (platelets 36,000).
Reading words versus seeing font or handwriting style: a study of hemifield processing.
Exp Brain Res
January 2025
Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, Canada.
Tachistoscopic studies have established a right field advantage for the perception of visually presented words, which has been interpreted as reflecting a left hemispheric specialization. However, it is not clear whether this is driven by the linguistic task of word processing, or also occurs when processing properties such as the style and regularity of text. We had 23 subjects perform a tachistoscopic study while they viewed five-letter words in either computer font or handwriting.
View Article and Find Full Text PDFNeighborhood-level socioeconomic disadvantage is associated with multiple cognitive domains in a community sample of older adults.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn
January 2025
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Greater neighborhood disadvantage is associated with poorer global cognition. However, less is known about the variation in the magnitude of neighborhood effects across individual cognitive domains and whether the strength of these associations differs by individual-level factors. The current study investigated these questions in a community sample of older adults ( = 166, mean age = 72.
View Article and Find Full Text PDFAuthors' Reply "Effect of Adiposity Status on Salivary Streptococcus mutans and Streptococcus sobrinus." Oral Diseases. Advance Online Publication. https://doi.org/10.1111/odi.15111.
Oral Dis
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