AI Article Synopsis
- - The study aimed to compare the effectiveness of multiple doses of vaginal clindamycin versus a single oral dose of secnidazole in treating bacterial vaginosis, using a double-blinded randomized controlled trial format.
- - Conducted at Shifa Foundation Community Health Center between March 2012 and February 2015, participants were divided into two groups: one receiving clindamycin and the other receiving secnidazole, with treatment success measured after 15 days.
- - Results showed that 96.6% of participants treated with vaginal clindamycin were cured of bacterial vaginosis, compared to only 23% in the secnidazole group, indicating that clindamycin is more effective for this condition.*
Article Abstract
Objective: To compare the efficacy of multiple doses of vaginal clindamycin with a single oral dose of secnidazole for the treatment of bacterial vaginosis.
Study Design: Double-blinded randomized controlled trial.
Place And Duration Of Study: Shifa Foundation Community Health Center, from March 2012 till February 2015.
Methodology: After obtaining written informed consent, a pelvic examination was performed for the confirmation of symptoms of milky white vaginal discharge on speculum examination, positive Amine test and presence of clue cells on microscopy. Pregnant women, known diabetes or any immunocompromised condition, were excluded. Blinding of the patient, doctor, and the pharmacist was done. Study cohort was then divided into two groups, Group Areceived medicine pack Awhich contained active clindamycin and placebo oral preparation, whereas group B was given pack B which contained active 2-gm secnidazole with placebo vaginal cream. Primary outcome and therapeutic success were defined by correction of two out of three (normal Nugent score, negative Amine test, and no milky white discharge) on day 15.
Results: At 15th day of treatment, 96.6% participants in vaginal clindamycin group (Group A), recovered from the bacterial vaginosis; whereas, (group B) 23% patients were cured in oral secnidazole group.
Conclusion: Multiple doses of vaginal clindamycin are superior to single dose of oral secnidazole for the treatment of bacterial vaginosis.
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