AI Article Synopsis
- The study examined how well cartilage interacted with hydrogels made of polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP), using a special testing setup to simulate wear conditions.
- Results showed that the PVA/PVP hydrogels had low friction coefficients that were closer to natural cartilage compared to traditional materials like stainless steel, although friction increased with higher hydrogel concentrations and lower PVP content.
- While the surface of the cartilage experienced minor wear, the hydrogels themselves showed more significant deformation, indicating potential for use in joint replacement but needing improvements in their mechanical properties for effective clinical application.
Article Abstract
This research investigated in-vitro tribological performance of the articulation of cartilage-on- polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) blend hydrogels using a custom-designed multi-directional wear rig. The hydrogels were prepared by repeated freezing-thawing cycles at different concentrations and PVA to PVP fractions at a given concentration. PVA/PVP blend hydrogels showed low coefficient of friction (COF) values (between 0.12 ± 0.01 and 0.14 ± 0.02) which were closer to the cartilage-on-cartilage articulation (0.03 ± 0.01) compared to the cartilage-on-stainless steel articulation (0.46 ± 0.06). The COF increased with increasing hydrogel concentration (p = 0.03) and decreasing PVP content at a given concentration (p < 0.05). The cartilage-on-hydrogel tests showed only the surface layers of the cartilage being removed (average volume loss of the condyles was 12.5 ± 4.2mm). However, the hydrogels were found to be worn/deformed. The hydrogels prepared at a higher concentration showed lower apparent volume loss. A strong correlation (R = 0.94) was found between the COF and compressive moduli of the hydrogel groups, resulting from decreasing contact congruency. It was concluded that the hydrogels were promising as hemiarthroplasty materials, but that improved mechanical behaviour was required for clinical use.
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| http://dx.doi.org/10.1016/j.jmbbm.2017.10.027 | DOI Listing |
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