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The guanine nucleotide exchange factor DOCK5 negatively regulates osteoblast differentiation and BMP2-induced bone regeneration via the MKK3/6 and p38 signaling pathways.
Exp Mol Med
January 2025
Department of Pathology and Regenerative Medicine, School of Dentistry, IHBR, Kyungpook National University, Daegu, 41940, Republic of Korea.
DOCK5 (dedicator of cytokinesis 5), a guanine nucleotide exchange factor for Rac1, has been implicated in BMP2-mediated osteoblast differentiation, but its specific role in osteogenesis and bone regeneration remained unclear. This study investigated the effect of DOCK5 on bone regeneration using C21, a DOCK5 chemical inhibitor, and Dock5-deficient mice. Osteoblast differentiation and bone regeneration were analyzed using bone marrow mesenchymal stem cells (BMSCs) and various animal models.
View Article and Find Full Text PDFPleomorphic dermal sarcoma of the scalp with intracranial space involvement: management of a rare entity. Illustrative case.
J Neurosurg Case Lessons
December 2024
Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli," Naples, Italy.
Background: Exophytic tumors of the calvaria (ETCs) remain a challenging pathology because of their complex management. The authors discuss the case of a woman with a large exophytic mass of the right frontotemporal region and underline their decision-making process on the management of this unique case and possible similar ones.
Observations: Neuroradiological findings showed a calvarial tumor with both epicranial and intracranial extension involving the frontotemporal bone with a mixed component (lytic and sclerotic) and dural infiltration with a pseudonodular pattern.
Computed tomographic findings in 25 cats with ear canal neoplasia.
Vet Radiol Ultrasound
January 2025
Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Computed tomography is commonly used to evaluate feline otic disease; however, published studies characterizing the CT appearance of ear canal neoplasia are limited. The purpose of this multicenter, retrospective, secondary analysis, cross-sectional study was to describe the CT features of histopathologically confirmed feline ear canal neoplasia. The CT studies of 25 cats with ear canal neoplasia were prospectively scored by consensus of two veterinary radiologists.
View Article and Find Full Text PDFA gigantic intraosseous and dural-based calvarial metastatic follicular thyroid carcinoma: illustrative case.
J Neurosurg Case Lessons
December 2024
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California.
Background: Metastatic follicular thyroid carcinoma to the central nervous system (CNS), including the skull and dura, is exceedingly rare.
Observations: The authors present the case of a gigantic, intraosseous, dural-based follicular thyroid carcinoma, highlighting the operative strategy for this mass. They also provide a literature review of CNS metastases of differentiated thyroid carcinoma.
Calvarial Tuberculosis: Shifting Paradigm from Surgical to Conservative Approach.
Asian J Neurosurg
December 2024
Department of Neurosurgery, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
Article Synopsis
- * A study analyzed 15 patients with calvarial TB treated in Haryana from 2018 to 2021, noting that symptoms included scalp swelling and pain, with many patients having a history of pulmonary TB or HIV.
- * Most patients were treated conservatively with procedures like fine-needle aspiration, while a few required surgery; the outcomes highlighted the need for timely and appropriate management due to serious complications.
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