Anatomically realistic numerical breast models are essential tools for microwave breast imaging, supporting feasibility analysis, performance verification, and design improvements. Patient-specific models also assist in interpreting the results of the patient studies conducted on microwave imaging prototype systems. The proposed method employs automated and robust 3D processing techniques to construct flexible and reconfigurable breast models. These techniques include noise and artifact suppression with a principal component analysis (PCA) approach, and oversampling of the magnetic resonance imaging (MRI) data to enhance the intensity continuity. The k-means clustering segmentation identifies fatty and fibroglandular tissues and further segments these regions into a selected number of tissues, providing reconfigurable models. A peak Gaussian fitting technique maps the model clusters to the dielectric properties. The robustness of the proposed method is verified by applying it to both 1.5- and 3-T MRI scans as well as to scans of varying breast densities.
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http://dx.doi.org/10.1007/s11517-017-1740-9 | DOI Listing |
Front Immunol
January 2025
Key Lab of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: Breast cancer (BC) is the most prevalent malignant tumor in women, with triple-negative breast cancer (TNBC) showing the poorest prognosis among all subtypes. Glycosylation is increasingly recognized as a critical biomarker in the tumor microenvironment, particularly in BC. However, the glycosylation-related genes associated with TNBC have not yet been defined.
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January 2025
Departments of Clinical Pathology, The Second Affiliated Hospital of Medical College of Zhejiang University, Hangzhou, Zhejiang, China.
Objective: Breast cancer stands as the most prevalent form of cancer among women globally. This heterogeneous disease exhibits varying clinical behaviors. The stratification of breast cancer patients into risk groups, determined by their metastasis and survival outcomes, is pivotal for tailoring personalized treatments and therapeutic interventions.
View Article and Find Full Text PDFHeliyon
January 2025
UdA-TechLab, Research Center, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Survival rate of head and neck squamous cell carcinomas (HNSCC) patients are still to date very poor, and the application of innovative clinical approaches are urgently needed. Cold atmospheric plasmas (CAPs) are partially ionized gases that have shown anti-tumor effectiveness over a wide range of cancer types with potential application into clinics. However, the comprehension of the mechanisms underlying indirect CAP effects plays a key role for the prediction of treatment outcomes.
View Article and Find Full Text PDFAJPM Focus
February 2025
Department of Medicine, University of Washington School of Medicine, Seattle, Washington.
Introduction: Patient portals may facilitate breast cancer screening and could be an important factor to address inequities; however, this association is not well characterized. The authors sought to examine this association in a large academic health system to inform interventions to address breast cancer screening inequities.
Methods: The authors conducted a cross-sectional study among Black patients in a large academic health system using logistic regression to examine the association between breast cancer screening and portal use, adjusting for multilevel covariates and interactions.
Ultrason Imaging
January 2025
Department of Ultrasound, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.
This study aims to establish and validate an ultrasound radiomics nomogram for preoperative prediction of central lymph node metastasis in papillary thyroid microcarcinoma (PTMC) before operation. A retrospective analysis conducted on ultrasonic images and clinical features derived from 288 PTMC patients, who were divided into training cohorts ( = 201) and validating cohorts ( = 87) in a ratio of 7:3 base on the principle of random allocation. Radiomics features were extracted from the PTMC patients after ultrasonic examination, followed by dimension reduction and characteristic selection to construct the radiomics score (Radscore) using LASSO regression analysis.
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