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The Evolving Features of Takotsubo Syndrome.
Curr Cardiol Rep
January 2025
Berne Cardiovascular Research Center and Division of Cardiology, University of Virginia, Charlottesville, USA.
Purpose Of The Review: Takotsubo syndrome (TTS) is a transient form of left ventricular dysfunction, typically affecting post-menopausal females, often preceded by emotional or physical stressful events that act as triggers. Initially believed to be a rare and benign condition for its reversible nature, TTS has recently emerged as a complex multifaceted clinical entity, with heterogenous clinical presentations and a non-negligible risk of serious in-hospital complications, including acute heart failure, arrhythmias and death.
Recent Findings: Emerging pathophysiological hypotheses, ranging from microvascular dysfunction to systemic inflammation, offer new insights into the underlying mechanisms of TTS.
Prognostic Value of Frailty in Patients With Takotsubo Cardiomyopathy.
Clin Cardiol
January 2025
Unidad de Revisiones Sistemáticas y Meta-análisis (URSIGET), Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima, Peru.
Background: There is scarce data on the prognostic value of frailty in patients with Takotsubo cardiomyopathy (TCM). This study aimed to assess the association between frailty and in-hospital outcomes in patients with TCM.
Methods: Adult admissions with TCM were included using the 2016-2019 National Inpatient Sample database.
Critical Convex-Type ST Elevation Correlate With Ventricular Tachyarrhythmia in Takotsubo Cardiomyopathy.
Clin Cardiol
December 2024
Department of Internal Medicine, Divisions of Cardiology, Lo-Hsu Medical Foundation Lotung Poh-Ai Hospital, Yilan County, Taiwan.
Article Synopsis
- * Out of 55 patients, those with critical ECG patterns experienced a much higher rate of VT (43.8% vs. 2.6%) and in-hospital death (25.0% vs. 5.1%), highlighting the serious nature of these ECG presentations.
- * Critical ECG types and an extended QRS width (≥105 ms) were identified as independent risk factors for both VT and poor overall prognosis, emphasizing the importance of monitoring these electrical patterns in
Psychosocial and psychopathological dimensions of patients with Takotsubo Syndrome.
Panminerva Med
December 2024
Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.
Article Synopsis
- Takotsubo syndrome (TTS) primarily affects post-menopausal women and can be triggered by stress, resembling acute coronary syndrome without actual coronary blockage.
- The study involved 40 female participants divided into groups of TTS patients, healthy individuals, psychiatric patients, and ACS patients, assessing various psychosocial and psychological factors through interviews.
- The findings indicated that TTS patients had significant differences in measures of psychological trauma and cyclothymia compared to the ACS and other groups, highlighting their unique psychological profile linked to the syndrome.
Prevalence of neurogenic stress cardiomyopathy in acute ischemic stroke and relationship with leukocytosis.
J Stroke Cerebrovasc Dis
January 2025
Temple University Hospital, Department of Neurology, 3401 N. Broad St., Ste. C525, Philadelphia, PA 19140. Electronic address:
Article Synopsis
- Neurogenic stress cardiomyopathy (NSC) was found in 21% of 688 adult ischemic stroke patients, with characteristics including a mean age of 68, low left ventricular ejection fraction in 64%, and elevated Troponin-I in 40% of cases.
- The study analyzed various stroke mechanisms, revealing that 43% were cryptogenic and showed that 12% of patients with NSC experienced leukocytosis, but this was not significantly different from the 8% in patients without NSC.
- The findings suggest a need to define neurogenic stress cardiomyopathy based on specific cardiac biomarkers and highlight the importance of further research to pinpoint its risk factors.*
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