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Introduction: Although maintenance treatment is recommended for the prevention of relapse, in real-world settings, a subset of patients discontinue antipsychotics while having a good prognosis. The prediction of functional remission in patients with schizophrenia after antipsychotic discontinuation (FURSAD) study aims to obtain real-world knowledge regarding the characteristics of schizophrenia (SCZ) patients who achieve functional remission after antipsychotic discontinuation for 1 year or more. This study also aims to establish a prediction model to identify patients likely to benefit from antipsychotic discontinuation.
View Article and Find Full Text PDFAppropriate use of single-dose injectable aripiprazole lauroxil in the treatment of schizophrenia.
Ment Health Clin
December 2024
(Corresponding author) Associate Professor, Department of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia, Athens, GA,
Introduction: Single-dose injectable aripiprazole lauroxil (SDIAL) is used with long-acting injectable (LAI) aripiprazole lauroxil in the treatment of schizophrenia. SDIAL can be used to either initiate treatment or supplement during maintenance when follow-up doses are not given within labeling recommendations. The primary objective was to determine the usage and appropriateness of SDIAL between the initiation and the maintenance supplementation use in a Medicaid database.
View Article and Find Full Text PDFPharmacist-led Si-care (schizophrenia care) model to improve medication adherence and symptom management in schizophrenia.
Explor Res Clin Soc Pharm
December 2024
School of Allied Health and Physical Activity for Health, Health Research Institute (HRI), University of Limerick, Limerick, Ireland.
Introduction: Schizophrenia is a chronic mental disorder that requires long-term treatment, particularly antipsychotic medications. However, medication adherence among patients with schizophrenia is often suboptimal, leading to symptom relapse and poor outcomes. The Si-Care (Schizophrenia Care) program was developed as a pharmacist-led home intervention to improve medication adherence and support symptom control in patients with schizophrenia.
View Article and Find Full Text PDFGlial cell deficits are a key feature of schizophrenia: implications for neuronal circuit maintenance and histological differentiation from classical neurodegeneration.
Mol Psychiatry
December 2024
Department of Psychiatry, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
Dysfunctional glial cells play a pre-eminent role in schizophrenia pathophysiology. Post-mortem studies have provided evidence for significantly decreased glial cell numbers in different brain regions of individuals with schizophrenia. Reduced glial cell numbers are most pronounced in oligodendroglia, but reduced astrocyte cell densities have also been reported.
View Article and Find Full Text PDFNurse Counseling versus IEC Material on Maintenance of Healthy Lifestyle for Outpatients Receiving Antipsychotics: A Randomized Control Trial.
Indian J Psychol Med
September 2024
Dept. of Biostatistics, NIMHANS (INI), Bengaluru, Karnataka, India.
Background: A healthy lifestyle is important for recovery, coping with life's stresses, minimizing the occurrence and impact of health issues, and improving quality of life. Maintaining a healthy lifestyle may help in preventing or delaying the onset of many health problems.
Methods: A quantitative research approach with a randomized control trial (RCT) was adopted.
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