Posttransplant lymphoproliferative disorders (PTLD) represent an immunosuppression-related lymphoid or plasmacytic proliferation that occur in the setting of solid organ transplant or allogeneic hematopoietic stem cell transplantation (HSCT). PTLD is a devastating consequence of HSCT and solid organ transplantation with a high morbidity and mortality. Most commonly, PTLD is related to Epstein-Barr virus (EBV) infection, but an increasing number of non-EBV-related cases are occurring. Initial therapy involves withdrawal of immunosuppression with or without antibody or cytotoxic chemotherapy. Novel therapeutic approaches including EBV-specific cytotoxic T lymphocytes are currently being studied.
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http://dx.doi.org/10.1016/j.ccm.2017.08.001 | DOI Listing |
Nurs Manage
January 2025
At NewYork-Presbyterian Hospital in New York, N.Y., Barbara Alba is the director of Maternal Child Health; Gwen Mancuso is the manager of the Behavioral Health Admission Center; Kerry Hensler is the director of Nursing, Perioperative Services; and Devon Nicholas is the manager of Solid Organ Transplant.
J Immunother Precis Oncol
February 2025
Section of Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Thrombotic thrombocytopenic purpura (TTP) is characterized by thrombotic microangiopathy resulting from decreased activation of the von Willebrand factor-cleaving protease (ADAMTS13). TTP can cause organ damage and is often fatal if the appropriate treatment is not started immediately. Although primary immune TTP is the most common form of TTP, secondary immune etiologies, including complications from immune checkpoint inhibitors (ICIs), have also been reported.
View Article and Find Full Text PDFHeliyon
January 2025
Functional Omics and Bioprocess Development Laboratory, Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.
Eutrophication and hypereutrophication in lakes foster harmful blue-green algal blooms, which pose a significant threat to the ecological health of freshwater reservoirs. This study investigated the effectiveness of the bio-flocculation approach using the fungus strain BGF4A1 to remove these harmful blooms, specifically targeting cyanobacterial species like PCC-7914. Key flocculation parameters, cyanobacterial concentrations, adsorption kinetics, and pellet morphology were explored in this research.
View Article and Find Full Text PDFExp Clin Transplant
December 2024
>From the Department of Pulmonary Diseases, Başkent University, Faculty of Medicine, Ankara, Turkey.
Objectives: Respiratory tract infections are commonly seen and compose a great burden on health care. The causing pathogens might be either bacteria or viruses. Because treatment is different for each, prompt diagnosis and early treatment are crucial, especially in immunocompromised patients like solid-organ transplant recipients who often present with obscure findings.
View Article and Find Full Text PDFMedicine (Baltimore)
November 2024
Department of Obstetrics & Gynecology, Chungnam National University School of Medicine, Chungnam National University Sejong Hospital, Sejong, Republic of Korea.
The use of neoadjuvant chemotherapy (NAC) as a first-line therapy for advanced high-grade serous ovarian carcinoma (HGSOC) has increased. However, several studies have reported NAC-induced platinum resistance. This study aimed to evaluate the predictive impact of clinical factors on chemotherapy response score (CRS) and to select patients who would respond well to NAC.
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