Posttransplant Lymphoproliferative Disorder in Solid Organ and Hematopoietic Stem Cell Transplantation.

Clin Chest Med

Department of Medicine, Division of Hematology and Oncology, Hospital of the University of Pennsylvania, Perelman Center for Advanced Medicine, West Pavilion, 4th Floor, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address:

Published: December 2017

Posttransplant lymphoproliferative disorders (PTLD) represent an immunosuppression-related lymphoid or plasmacytic proliferation that occur in the setting of solid organ transplant or allogeneic hematopoietic stem cell transplantation (HSCT). PTLD is a devastating consequence of HSCT and solid organ transplantation with a high morbidity and mortality. Most commonly, PTLD is related to Epstein-Barr virus (EBV) infection, but an increasing number of non-EBV-related cases are occurring. Initial therapy involves withdrawal of immunosuppression with or without antibody or cytotoxic chemotherapy. Novel therapeutic approaches including EBV-specific cytotoxic T lymphocytes are currently being studied.

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http://dx.doi.org/10.1016/j.ccm.2017.08.001DOI Listing

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