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Elevated protein lactylation promotes immunosuppressive microenvironment and therapeutic resistance in pancreatic ductal adenocarcinoma.
J Clin Invest
January 2025
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Metabolic reprogramming shapes tumor microenvironment (TME) and may lead to immunotherapy resistance in pancreatic ductal adenocarcinoma (PDAC). Elucidating the impact of pancreatic cancer cell metabolism in the TME is essential to therapeutic interventions. "Immune cold" PDAC is characterized by elevated lactate levels resulting from tumor cell metabolism, abundance of pro-tumor macrophages, and reduced cytotoxic T cell in the TME.
View Article and Find Full Text PDFUnique hierarchical NiFe-LDH/Ni/NiCoS heterostructure arrays on nickel foam for the improvement of overall water splitting activity.
Nanoscale
January 2025
Chongqing Key Laboratory of Inorganic Functional Materials, College of Chemistry, Chongqing Normal University, Chongqing, 401331, PR China.
The development of environmentally friendly, high-efficiency, stable, earth-abundant and non-precious metal-based electrocatalysts with fast kinetics and low overpotential for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) is of exceeding significance but still challenging. Herein, a bifunctional electrode of unique hierarchical NiFe-LDH/Ni/NiCoS/NF (NiFe-LDH = nickel-iron layered double hydroxide and NF = nickel foam) electrocatalytic architecture, which is built up from NiFe-LDH nanosheets, Ni nanoparticles and NiCoS nanoneedles sequentially arrayed on a porous NF substrate, has been prepared by a facile hydrothermal and electrodeposition method. This electrocatalytic architecture is binder-free and its outer NiFe-LDH nanosheets can effectively prevent the oxidation of inner Ni nanoparticles and corrosion of NiCoS nanoneedles during water electrolysis.
View Article and Find Full Text PDFEarly life adverse environmental, nutrition and infection factors are associated with lower developmental scores in Pakistani children at 5 years: a cohort study.
BMJ Nutr Prev Health
November 2024
Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.
Background: The effects of multiple early adverse psychosocial and biological factors on child development at preschool age in deprived settings are not fully understood.
Methods: The 'Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development' (MAL-ED) project followed children from eight countries, recording sociodemographic, nutritional, illness, enteroinfection biomarkers and scores for quality of home environment (Home Observation for Measurement of the Environment (HOME)), development (Bayley) and maternal depression during the first year of life. In the Pakistan cohort, we investigated associations of these early factors with Z-scores (derived from the eight participating countries) of three developmental outcomes at 5 years: Executive Functions (Z-EF), the Wechsler Preschool and Primary Scale for Intelligence (Z-WPPSI) and the externalising behaviours component of the Strength and Difficulties test (Z-externalising behaviours).
Hydrogen production by suspension self-rotation enhanced pyrolysis of sludge particles in cyclone.
Water Res
January 2025
National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery, East China University of Science and Technology, Shanghai, 200237, China. Electronic address:
The challenges faced by sludge pyrolysis units, including poor heat transfer efficiency and uneven heating of material groups, significantly hinder the green and low-carbon transformation and sustainable development of sludge treatment. The suspension self-rotation of sludge particles in a cyclone enhances particle heat transfer, thereby improving the pyrolysis process. In this study, we developed a novel method for sludge pyrolysis using Cyclone Suspension Self-Rotation Pyrolysis Reactor (CSSPR).
View Article and Find Full Text PDFPolyp and tumor microenvironment reprogramming in colorectal cancer: insights from mucosal bacteriome and metabolite crosstalk.
Ann Clin Microbiol Antimicrob
January 2025
Department of Science and Environment, Roskilde University, Roskilde, Denmark.
Background: Highly frequent colorectal cancer (CRC) is predicted to have 3.2 million novel cases by 2040. Tumor microenvironment (TME) bacteriome and metabolites are proposed to be involved in CRC development.
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