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Blood microbiota in HIV-infected and HIV-uninfected patients with suspected sepsis detected by metagenomic next-generation sequencing.
BMC Infect Dis
October 2024
Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Article Synopsis
- The study investigates the differences in blood microbiota between HIV-infected and uninfected patients suspected of having sepsis, using metagenomic next-generation sequencing (mNGS).
- It analyzed 233 patients, revealing that HIV-infected individuals had a higher presence of mycobacterium, fungi, and viruses, while bacterial levels were lower compared to their uninfected counterparts.
- Key findings highlighted elevated rates of non-tuberculous mycobacteriosis, Pneumocystis jirovecii, Talaromyces marneffei, and cytomegalovirus in HIV-infected patients, indicating significant disparities in their blood microbiota profiles.
Synthesis and broad-spectrum biocidal effect of novel gemini quaternary ammonium compounds.
Bioorg Chem
October 2024
Department of Epidemiology, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. Electronic address:
Article Synopsis
- The misuse of antibiotics has led to the rise of resistant bacteria and the need for new antimicrobial solutions, highlighting the potential of 'gemini' quaternary ammonium compounds (QACs) like octenidine (OCT).
- Researchers developed 16 novel OCT derivatives, which were tested for effectiveness against resistant bacteria, showing that compounds 6-8 were notably more effective than existing standards, and compound 12 exhibited low toxicity and broad-spectrum antimicrobial activity.
- Several of the new compounds, particularly compound 12, demonstrated strong antifungal and virucidal activity, positioning them as promising alternatives to current disinfectants in combating resistant strains.
Life-threatening gastrointestinal bleeding caused by cytomegalovirus-induced duodenal ulcer in a patient with AIDS: A case report.
Heliyon
May 2024
Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China.
Background: The reasons for gastrointestinal bleeding among patients with acquired immune deficiency syndrome (AIDS) were complex. Here we present an unusual case of life-threatening gastrointestinal bleeding caused by a cytomegalovirus-induced duodenal ulcer in an AIDS patient.
Case Presentation: A 31-year-old male with AIDS was admitted on July 18, 2023, complaining of abdominal pain for 38 days and intermittent hematochezia for 12 days.
Microbiomes detected by cerebrospinal fluid metagenomic next-generation sequencing among patients with and without HIV with suspected central nervous system infection.
HIV Med
July 2024
Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Background: Opportunistic infections in the central nervous system (CNS) can be a serious threat to people living with HIV. Early aetiological diagnosis and targeted treatment are crucial but difficult. Metagenomic next-generation sequencing (mNGS) has significant advantages over traditional detection methods.
View Article and Find Full Text PDFAIDS-related gastrointestinal cytomegalovirus end-organ disease: A retrospective cohort study at a tertiary center in São Paulo, Brazil.
Int J STD AIDS
April 2024
Departamento de Neurologia, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil.
Background: Current information about AIDS-related gastrointestinal cytomegalovirus end-organ disease (CMV-EOD) is scarce. The objectives of this study were to identify the prevalence and main features of gastrointestinal CMV-EOD in patients with advanced HIV disease.
Methods: Retrospective cohort study carried-out at a tertiary-care center in São Paulo, Brazil, from January to December 2019.
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