A microneedle patch containing melanin promotes systemic antitumor response upon photothermal irradiation.
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Atmospheric pah concentrations in a semi-urban site: temporal variation, risk assessment, source identification and estimation of levels in diverse environments.
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Department of Environmental Engineering, Faculty of Engineering, Bursa Uludag University, 16059 Nilüfer/Bursa-Türkiye.
This study evaluates atmospheric polycyclic aromatic hydrocarbon (PAH) concentrations in a semi-urban area, Görükle, Turkey, from June 2021 to February 2022. The average concentration of ∑16 PAHs was 24.85 ± 19.
View Article and Find Full Text PDFCytotoxic effects of the cigarette smoke extract of heated tobacco products on human oral squamous cell carcinoma: the role of reactive oxygen species and CaMKK2.
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Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan. Electronic address:
Background: The increasing prevalence of heated tobacco products (HTPs) has heightened concerns regarding their potential health risks. Previous studies have demonstrated the toxicity of cigarette smoke extract (CSE) from traditional tobacco's mainstream smoke, even after the removal of nicotine and tar. Our study aimed to investigate the cytotoxicity of CSE derived from HTPs and traditional tobacco, with a particular focus on the role of reactive oxygen species (ROS) and intracellular Ca.
View Article and Find Full Text PDFComputational Design of a Thermal Applicator for Brain Hyperthermia Controlled by Capacitor Positioning in Loop Coils.
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Department of Biomedical Engineering, Gachon University, Seongnam, Gyeonggi, Korea.
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View Article and Find Full Text PDFStudy of Histotripsy With Subsequent Heating on In Vitro VX2 Cancer Cells.
J Ultrasound Med
January 2025
Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Objective: Focused ultrasound has emerged as a precise and minimally invasive modality for effective cancer treatment. In this study, we propose a novel method that integrates the mechanical effects of focused ultrasound, known as histotripsy, with heating to enhance both the immediate and sustained cytotoxic effects on cancer cells.
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State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute. Ren Ji Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, P. R. China.
Hypoxia severely limits the antitumor immunotherapy for breast cancer. Although efforts to alleviate tumor hypoxia and drug delivery using diverse nanostructures achieve promising results, the creation of a versatile controllable oxygen-releasing nano-platform for co-delivery with immunostimulatory molecules remains a persistent challenge. To address this problem, a versatile oxygen controllable releasing vehicle PFOB@F127@PDA (PFPNPs) is developed, which effectively co-delivered either protein drug lactate oxidase (LOX) or nucleic acids drug unmethylated cytosine-phosphate-guanine oligonucleotide (CpG ODNs).
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