Anandins A () and B (), two rare steroidal alkaloids, were isolated from the fermentative broth of a marine actinobacteria H41-59. The gross structures of the two alkaloids were elucidated by spectroscopic methods including HR-ESI-MS, and NMR. Their absolute configurations were confirmed by single-crystal X-ray diffraction analysis and comparison of their experimental and calculated electronic circular dichroism spectra, respectively. Anandin A exhibited a moderate inhibitory effect against three human cancer cell lines MCF-7, SF-268, and NCI-H460 with IC values of 7.5, 7.9, 7.8 μg/mL, respectively.
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| http://dx.doi.org/10.3390/md15110355 | DOI Listing |
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Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59.
Mar Drugs
November 2017
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Product, College of Pharmacy, Jinan University, Guangzhou 510632, China.
Anandins A () and B (), two rare steroidal alkaloids, were isolated from the fermentative broth of a marine actinobacteria H41-59. The gross structures of the two alkaloids were elucidated by spectroscopic methods including HR-ESI-MS, and NMR. Their absolute configurations were confirmed by single-crystal X-ray diffraction analysis and comparison of their experimental and calculated electronic circular dichroism spectra, respectively.
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