AI Article Synopsis
- The study investigates the long-term effects of IDSA treatment guidelines on patients with methicillin-susceptible S. aureus (MSSA) prosthetic joint infections (PJI).
- Non-compliance with these guidelines significantly increased the risk of treatment failure, with a hazard ratio indicating over twice the risk.
- For patients not suitable for keeping the implant, complete removal is recommended to reduce the chances of treatment failure.
Article Abstract
Objective: The long-term impact of treatment strategies proposed by the IDSA guidelines for patients presenting with methicillin-susceptible S. aureus (MSSA) prosthetic joint infection (PJI) is not well-known.
Patients And Methods: Retrospective (2000-2010) cohort study including patients presenting with MSSA hip or knee PJI. A univariate Cox analysis was performed to determine if the non-compliance with IDSA surgical guidelines was a risk factor for treatment failure.
Results: Eighty-nine patients with a mean follow-up of 2.8 years were included. Non-compliance with IDSA surgical guidelines was associated with treatment failure (hazard ratio 2.157; 95% CI [1.022-4.7]). The American Society of Anesthesiologists score, inadequate antimicrobial therapy, and a rifampicin-based regimen did not significantly influence patient outcome.
Conclusion: Based on the IDSA guidelines, if a patient presenting with MSSA PJI is not eligible for implant retention, complete implant removal is needed to limit treatment failure.
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| http://dx.doi.org/10.1016/j.medmal.2017.09.016 | DOI Listing |
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Article Synopsis
- The study investigates the long-term effects of IDSA treatment guidelines on patients with methicillin-susceptible S. aureus (MSSA) prosthetic joint infections (PJI).
- Non-compliance with these guidelines significantly increased the risk of treatment failure, with a hazard ratio indicating over twice the risk.
- For patients not suitable for keeping the implant, complete removal is recommended to reduce the chances of treatment failure.
Adult community-acquired bacterial meningitis requiring ICU admission: epidemiological data, prognosis factors and adherence to IDSA guidelines.
Eur J Clin Microbiol Infect Dis
November 2009
Intensive Care and Infectious Disease Unit, Tourcoing Hospital, 135 rue du Président Coty, BP 619, 59208 Tourcoing cedex, France.
Numerous guidelines are available to guide empirical antimicrobial therapy (EAT) in acute bacterial meningitis (ABM) patients. We analysed prognosis factors and compliance to the Infectious Diseases Society of America (IDSA) guidelines in ABM patients requiring stay in an intensive care unit (ICU). A 10-year retrospective study, using prospectively collected data, in 82 ABM patients admitted to a 16-bed university-affiliated French ICU was undertaken.
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