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Melasma management in primary care.
Aust J Gen Pract
December 2024
BPharm (UQ), Senior Pharmacist, Logan Hospital, Logan, Qld.
Background: Melasma, a condition characterised by hyperpigmented patches on the face, is one of the common skin conditions in women seeking treatment from primary care practitioners (PCPs). Several treatment modalities are available for PCPs as well as dermatologists. Each treatment option has its pros and cons, including accessibility and cost.
View Article and Find Full Text PDFDeep Dermal Dilemma: A Case Report on Majocchi's Granuloma After Topical Steroid Use.
Cureus
October 2024
Dermatology, Venereology, and Leprosy, Sri Ramaswamy Memorial (SRM) Medical College Hospital and Research Centre, Chennai, IND.
Article Synopsis
- Majocchi's granuloma is a dermatological condition where dermatophytes invade deeper skin layers, often triggered by trauma or excessive use of topical corticosteroids.
- A 57-year-old man experienced itchy skin lesions on his right ankle after using over-the-counter steroids, leading to the diagnosis of Majocchi's granuloma evidenced by clinical and histopathological findings.
- The patient was treated with oral terbinafine and topical luliconazole, resulting in resolution of lesions within three weeks, though he was advised to continue treatment for two months.
Investigation of the association of the MLPH gene with seasonal canine flank alopecia in Rhodesian Ridgeback dogs.
Canine Med Genet
October 2024
Expertise Centre of Genetics, Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Article Synopsis
- Canine flank alopecia (CFA) is a recurring skin condition in dogs, particularly affecting breeds like the Rhodesian Ridgeback, and is characterized by hair loss and skin darkening without inflammation.
- A study analyzed 24 dogs with CFA and 12 healthy controls, finding evidence of genetic inheritance but no significant differences linked to the melanophylin (MLPH) gene.
- Though pedigree analysis suggested a genetic influence on CFA, the MLPH gene was not implicated, indicating the need for further research to understand the genetic basis of CFA in these dogs.
Pathogenic Variants Resulting in Dural Based Fibroinflammatory Mass Lesions and H Syndrome Treated With Cobimetinib: A Case Report.
Neurol Genet
December 2024
From the Department of Neurology (S.A.B., A.J.A., G.F.K., N.K., W.O.T.); Division of Hematology (J.P.A., J.C.V., R.G.); Division of Hematopathology (K.R.); Division of Neuroradiology (P.M.); Department of Clinical Genomics (Q.K.G.T., L.N.V.); Division of General Internal Medicine (K.L.S.); Department of Dermatology (S.S.D., H.S.M.); Division of Endocrinology (C.J.D.-P.), Diabetes, Nutrition; and Center for Multiple Sclerosis and Autoimmune Neurology at Mayo Clinic (W.O.T.), Rochester, MN.
Objectives: Pathogenic variants are known to cause autosomal recessive disease with a spectrum of systemic involvement. We sought to expand on the spectrum of variants and describe potential treatment.
Methods: We describe a case of newly diagnosed -related disorder, also known as H syndrome or familial histiocytosis, associated with CNS inflammatory pseudotumor and spinal cord compression.
Malignant adnexal tumor harboring a somatic mutation in a woman previously diagnosed with mesothelioma, a case report.
Gynecol Oncol Rep
December 2024
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky, Lexington, KY 40536, USA.
Article Synopsis
- STK11 gene mutations are linked to Peutz-Jeghers syndrome, which increases the risk of various cancers, including gastrointestinal and breast cancers.
- The article describes a rare case of an STK11-associated adnexal tumor in a 39-year-old woman who previously had malignant mesothelioma.
- The need for careful diagnosis and further analysis of STK11 adnexal tumors is highlighted due to their uncommon occurrence and unclear pathology.
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