Four pregnant and four castrated ewes were chronically instrumented for the measurement of external iliac blood flow to test the hypothesis that pregnancy alters alpha-adrenergic sensitivity in a major regional circulation. Complete dose-response curves were generated to methoxamine, phenylephrine, and norepinephrine. Pregnancy was associated with no change in methoxamine sensitivity, an increase in phenylephrine sensitivity, and a decrease in norepinephrine sensitivity. These differential changes in drug sensitivity suggest (1) the alpha 1-receptor population is functionally similar between the two groups of animals, (2) uptake 1 is inhibited, and (3) either catechol-O-methyltransferase activity is increased or the alpha 2- or beta-receptor population changes in this circulation during pregnancy. These data illustrate the complexity of the change in the adrenergic system during pregnancy.
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