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Cost comparison of commonly used postoperative topical ophthalmic antibiotics. | LitMetric

Cost comparison of commonly used postoperative topical ophthalmic antibiotics.

J Cataract Refract Surg

From the Ruiz Department of Ophthalmology and Visual Science (Crowell, Koduri, Groat, Lee), McGovern Medical School at The University of Texas Health Science Center at Houston, and the Robert Cizik Eye Clinic (Crowell, Groat, Lee), Houston, Texas, USA. Electronic address:

Published: October 2017

AI Article Synopsis

Article Abstract

Purpose: To provide information on the actual fill level and cost of currently available antibiotic drops used perioperatively.

Design: Prospective laboratory investigation.

Setting: Robert Cizik Eye Clinic, Houston, Texas USA.

Methods: The following 9 medications were tested: moxifloxacin, gatifloxacin (branded and generic), besifloxacin, levofloxacin, ciprofloxacin, ofloxacin, trimethoprim/polymyxin B, tobramycin, and gentamicin. Actual bottle-fill volume and number of drops per bottle were measured using 10 bottles of each formulation. The percentage of the bottle used and the perioperative cost (using average wholesale price) were calculated for 3 times a day and 4 times a day dosing for 7-day, 10-day, and 14-day courses. Formulations were compared using 1-way analysis of variance with Tukey multiple comparisons.

Results: For medications with sticker volumes of at least 5 mL, all but 2 medications (ofloxacin, 4 times a day for 14 days; gentamicin, 4 times a day for 14 days) covered 2 perioperative courses. Besifloxacin had a fill volume less than the sticker volume. The most cost-effective perioperative antibiotic prophylaxis was trimethoprim-polymyxin B (4 times a day: $12.87 for 7-day, 10-day, and 14-day courses, and $46.88 for 4-day course; 3 times a day: $12.87 for 7-day, 10-day, and 14-day courses).

Conclusions: Most antibiotics had an actual fill volume greater than sticker volume, which is a sufficient drug regimen for 2 perioperative courses. The costs of common postoperative topical antibiotic regimens vary widely depending on the drug and dosing regimen. Cost considerations for perioperative antibiotics will be increasingly important because the number of cataract surgeries is expected to increase with the growing and aging population.

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Source
http://dx.doi.org/10.1016/j.jcrs.2017.07.028DOI Listing

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