AI Article Synopsis
- Garcinia mangostana L. is rich in xanthones, with a new compound identified as mangostanaxanthone VII, alongside four known xanthones from its pericarps.
- Structural analysis of these compounds was conducted using various techniques, such as UV, IR, NMR, and HRESIMS.
- Mangostanaxanthone VII exhibited moderate cytotoxicity against A549 and MCF-7 cancer cell lines and demonstrated antimicrobial properties against several bacterial and fungal strains.
Article Abstract
Garcinia mangostana L. (the queen of fruits, mangosteen, family Guttiferae) is a wealthy source of xanthones. The CHCl3 soluble fraction of the air-dried pericarps of G. mangostana provided a new xanthone: mangostanaxanthone VII (5), along with four known xanthones: mangostanaxanthones I (1) and II (2), gartanin (3) and γ-mangostin (4). The structural verification of these metabolites was achieved by different spectral techniques, including UV, IR, 1D and 2D NMR and HRESIMS. The new metabolite was assessed for cytotoxic potential, using sulforhodamine B (SRB) assay towards the A549 and MCF-7 cancer cell lines. Moreover, its antimicrobial effects were evaluated against various bacterial and fungal strains, using agar disc diffusion assay. Mangostanaxanthone VII showed moderate cytotoxic activity against the A549 and MCF7 cell lines with IC50s 26.1 and 34.8 μM, respectively, compared with doxorubicin (0.74 and 0.41 μM, respectively).
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| http://dx.doi.org/10.1515/znc-2017-0122 | DOI Listing |
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