AI Article Synopsis
- Patients over 75 make up a significant portion of myocardial infarction cases and experience high in-hospital mortality, yet there are no tailored management guidelines for acute coronary syndromes (ACS) in this age group.
- Antithrombotic therapy can be beneficial for elderly patients but requires careful adjustments due to an increased risk of bleeding from factors like renal issues and malnutrition.
- Research on elderly patients in clinical trials is limited, necessitating modifications to antithrombotic therapy to minimize bleeding risks while maintaining treatment effectiveness, as reviewed in current ACS strategies.
Article Abstract
Background: Patients over 75 account for more than one third of those presenting with myocardial infarction and more than 50% of intrahospital mortality. There are no specific guidelines for the management of acute coronary syndromes (ACS) in the elderly.
Setting: Although antithrombotic therapy seems to be effective and safe in such patients, it requires specific precautions and treatment adjustments because of the higher bleeding risk due to comorbidities such as renal function impairment and malnutrition.
Results: Scientific evidence concerning elderly patients is scarce as they are either excluded or underrepresented in most randomized trials. Overall, the antithrombotic therapy needs to be adapted to avoid complications, mainly bleeding complications, without compromising the effectiveness of the treatment in this high-risk population.
Conclusion: In the present paper, we review the current treatment strategies in ACS while focusing on data concerning the elderly, according to available data in pivotal trials and in both AHA/ACC and ESC guidelines.
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| http://dx.doi.org/10.1007/s10557-017-6761-y | DOI Listing |
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