AI Article Synopsis
- Changes in endometrial cell morphology and function are crucial for embryo implantation, and miR-26a is a key regulator in dairy goats' endometrial cells.
- MiR-26a is influenced by hormones like β-estradiol and progesterone and affects cell proliferation and apoptosis by modulating pathways linked to PTEN and PI3K/AKT.
- The study highlights the complex role of miR-26a in regulating important proteins in endometrial cells, contributing to our understanding of endometrial receptivity and embryo implantation in dairy goats.
Article Abstract
Changes in endometrial cell morphology and function are absolutely necessary for successful embryo implantation. In this study, miR-26a was widely expressed in dairy goats, and was found to be regulated by β-estradiol (E2) and progesterone (P4) in endometrial epithelium cells (EECs) as well as stromal cells (ESCs). Furthermore, miR-26a played a role in the regulation of cells proliferation and apoptosis by directly regulating PTEN and indirectly regulating the PI3K/AKT pathway in EECs but not in ESCs of dairy goats in vitro. In addition, miR-26a regulated the expression of osteopontin (OPN), vascular endothelial growth factor (VEGF), Cyclooxygenase-2 (COX-2), and prolactin (PRL) in endometrial cells. Therefore, we could get a conclusion that miR-26a had very complex and diverse functions in the endometrial cells during the development of endometrial receptivity in dairy goats. This study provided an efficient platform for studying the regulatory effect of miR-26a on endometrial cells during the development of endometrial receptivity in dairy goats.
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| http://dx.doi.org/10.1002/jcp.26252 | DOI Listing |
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