Association study between gene polymorphisms and obesity in Korean population.

The aim of this study is to investigate whether single nucleotide polymorphisms (SNPs) of zinc finger homeobox 3 ( ) gene are susceptibility to obesity. Recently, several study suggested that specific polymorphisms in various genes may have effect to obesity. In present study, 54 SNPs of gene were genotyped in 209 overweight and obese patients with a body mass index (BMI)≥23 kg/m (mean±standard deviation, 44.7±6.4 kg/m) and 159 healthy controls with a BMI of 18.5-23.0 kg/m (43.6±6.2 kg/m). Genotyping of each SNP was performed by custom DNA chip. Logistic regression models (dominant, recessive, and log-additive models) were used to calculate odds ratio, 95% confidence interval, and -values. Significant association was considered at <0.05. Among tested SNPs in genes, seven SNPs of gene showed significant association with obesity (<0.05 in each model, respectively). In conclusion, these results indicate that SNPs of gene might be contributed to development of obesity in the Korean population.