AI Article Synopsis
- A systematic review was conducted to identify risk factors for recurrence of squamous cell carcinoma in situ (SCCIS), focusing on various treatment approaches and factors linked to tumor recurrence.
- The analysis showed that immunosuppression was the only factor significantly associated with an increased risk of recurrence, while other possible contributors like tumor size and depth lacked strong supportive data.
- The authors concluded that recognizing factors such as subclinical tumor extension might be important in treatment decisions for SCCIS and emphasized the need for further research to better understand recurrence risks and treatment efficacy.
Article Abstract
Background: Numerous treatment modalities have been reported for squamous cell carcinoma in situ (SCCIS). Risk factors for recurrence have not been systematically reviewed.
Objective: To systematically review and summarize the data on risk factors that contribute to recurrence of SCCIS.
Materials And Methods: A PubMed search was completed using the terms "SCCIS," "Bowen's disease," "Bowen's disease and recurrence," and "Bowen's disease and Mohs." These sources were cross-referenced for the terms "treatment," "management," "therapy," "recurrence," and "margins." Studies were selected on the basis of relevance and applicable treatments.
Results: Immunosuppression was the only variable with a statistically signficant association with progression or recurrence of SCCIS. Although there were no data directly correlating subclinical lateral extension or invasive squamous cell carcinoma within SCCIS with recurrence, evidence supports both of these as common features of SCCIS. Other potential recurrence risk factors for which there are limited supporting data included tumor size, depth of follicular extension, and location.
Conclusion: Immunosuppression was the only risk factor associated with increased risk of tumor recurrence. Subclinical tumor extension and occult invasive squamous cell carcinoma are relatively common features that theoretically could increase recurrence risk. These factors should be considered when deciding upon treatment for SCCIS. Further study is required to quantify variables that influence recurrence and to identify optimal treatment options.
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| http://dx.doi.org/10.1097/DSS.0000000000001400 | DOI Listing |
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