Background: Acromioplasty has been proposed as a means of altering elevated critical shoulder angles (CSAs). We aimed to localize the critical acromion point (CAP) responsible for the acromial contribution of the CSA and determine whether resection of the CAP can alter the CSA to a normal range.
Methods: The CAP and 3-dimensional (3D) CSAs were determined on 3D computed tomography reconstructions of 88 cadaveric shoulders and compared with corresponding CSAs on digitally reconstructed radiographs. The position of the CAP was fluoroscopically isolated in 20 of these specimens and the resulting fluoroscopic CSA compared with the corresponding 3D CAP and 3D CSA. We investigated the CSA before and after a virtual acromioplasty of 2.5 and 5 mm at the CAP in specimens with a CSA greater than 35°.
Results: The mean CAP was 21% ± 10% of the acromial anterior-posterior length from the anterolateral corner. There was no difference between the mean 3D CSA and the CSA on digitally reconstructed radiographs (32° vs 32°, P = .096). No difference between the mean fluoroscopic CSA and 3D CSA was found (31° vs 31°, P = .296). A 2.5-mm acromial resection failed to reduce the CSA to 35° or less in 7 of 13 shoulders, whereas a 5-mm resection reduced the CSA to 35° or less in 12 of 13.
Conclusion: The CAP was localized to the anterolateral acromial edge and was easily identified fluoroscopically. A 5-mm acromial resection was effective in reducing the CSA to 35° or less. These data can guide surgeons in where and how to alter the CSA if future studies demonstrate a clinical benefit to surgically modifying this radiographic parameter.
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http://dx.doi.org/10.1016/j.jse.2017.08.025 | DOI Listing |
Alzheimers Dement
December 2024
Indiana University, Bloomington, IN, USA.
Background: The roles of Aβ in the pathogenesis of Alzheimer 's disease (AD) include disruption of synaptic communication/function and synaptic plasticity mechanisms thought to underlie learning and memory. Exactly how these abnormal processes arise is incompletely understood, but evidence suggests that dysregulation of intracellular Ca levels is involved in alterations of neuronal excitability, synaptic remodeling, and neurodegeneration in AD. Our lab has focused on the potential involvement of voltage-gated potassium channels (VGKCs) in these processes, particularly Kv1.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Case Western Reserve University, Cleveland, OH, USA.
Background: Pathological tau forms from Alzheimer's disease (AD) brains act as seeds, replicating in cells and forming tau aggregates in a template-like manner. The exploration of this prion-like pathogenic mechanism has predominantly occurred in transgenic mice and cell systems that overexpress tau protein and its truncated forms with pro-aggregation mutations. However, these systems do not entirely capture the propagation kinetics and template conformational changes of various tau seeds.
View Article and Find Full Text PDFHeliyon
November 2024
Department of Management and Finance, Sher-e-Bangla Agricultural University, Dhaka, Bangladesh.
The issue of global climate change is increasingly worrisome, particularly for countries heavily reliant on agriculture. To reduce the negative impact of climate change on agriculture, farmers of Bangladesh started adopting different climate smart agriculture (CSA) practices. The CSA sustainably increases productivity, resilience, and food security, which can contribute to the achievement of a number of sustainable development goals (SDGs).
View Article and Find Full Text PDFBMC Med Educ
January 2025
School of Social and Behavioral Sciences, Nanjing University, Nanjing, 210008, China.
Background: Standardized postgraduate medical education (PGME) in anesthesiology is not well-defined in China. Establishing a competency framework for postgraduate anesthesia training (PGAT) is essential for standardizing and enhancing the quality of training and patient care.
Objectives: This study aimed to develop a competency framework for PGAT in China.
Nat Commun
January 2025
Key Laboratory for Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.
The preparation of single-crystal polymers with circularly polarized luminesce (CPL) remains a challenging task in chemistry and materials science. Herein, we present the single-crystal-to-single-crystal topochemical photopolymerization of a chiral organic salt to achieve this goal. The in-situ reaction of 1,4-bis((E)-2-(pyridin-4-yl)vinyl)benzene (1) with chiral (+)- or (-)-camphorsulfonic acid (CSA) gives the monomer crystal 1[( + )/( - )-CSA] showing yellow CPL with a high luminescent dissymmetry factor |g| of 0.
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