Herpesvirus sylvilagus is a lymphotropic (type gamma) herpesvirus of cottontail rabbits (Sylvilagus floridanus). Analysis of virion DNA of herpesvirus sylvilagus has revealed that the genome consists of one stretch of about 120 kilobase pairs of internal, unique DNA flanked by a variable number of 553-base-pair tandem repeats. The G + C content of the repetitive DNA is extremely high (83%), as determined by sequencing. The organization of the herpesvirus sylvilagus genome is, therefore, similar to that of the primate lymphotropic viruses herpesvirus saimiri and herpesvirus ateles.
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| http://dx.doi.org/10.1128/JVI.63.2.1010-1014.1989 | DOI Listing |
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Probable herpesvirus infection in an eastern cottontail (Sylvilagus floridanus).
J Wildl Dis
October 1992
Wisconsin Department of Agriculture, Trade & Consumer Protection, Wisconsin Animal Health Laboratory, Madison 53705.
One wild eastern cottontail (Sylvilagus floridanus) from Milwaukee County, Wisconsin was necropsied. The lungs contained numerous multifocal, circumscribed, tan foci; the spleen was markedly enlarged and had a mottled reddish tan color; and the brain had a red to tan friable tract in the left hemisphere. Microscopically, the lung had a severe bronchiolitis and pneumonia.
View Article and Find Full Text PDFImmune responses to Herpesvirus sylvilagus infection in cottontail rabbits.
J Immunol
September 1990
Department of Pediatrics, University of Massachusetts Medical Center, Worcester 01605.
Immunologic changes produced by Herpesvirus sylvilagus infection of cottontail rabbits were investigated to evaluate this virus infection system as an animal model for EBV infection in humans. H. sylvilagus neutralizing antibodies appeared as early as 7 days after infection, peaked 2 to 4 wk postinfection and decreased to low levels by 8 to 10 wk postinfection.
View Article and Find Full Text PDFGenome structure of cottontail rabbit herpesvirus.
J Virol
February 1989
Institut de Recherches Scientifiques sur le Cancer, Centre National de la Recherche Scientifique, Villejuif, France.
The genome structure of a herpesvirus isolated from primary cultures of kidney cells from the cottontail rabbit Sylvilagus floridanus was elucidated by using electron microscopy and restriction enzyme analysis. The genome, which was about 150 kilobase pairs long and which had an average G + C composition of 45%, consisted of two regions with unique base sequences (54 and 47 kilobase pairs) enclosed by reiterations of a 925-base-pair sequence with a variable copy number. The internal repeats were in opposite polarity with respect to the terminal repeats, and both unique regions underwent inversion.
View Article and Find Full Text PDFArrangement of repetitive sequences in the genome of herpesvirus Sylvilagus.
J Virol
February 1989
Department of Pharmacology, University of Massachusetts Medical School, Worcester 01655.
Herpesvirus sylvilagus is a lymphotropic (type gamma) herpesvirus of cottontail rabbits (Sylvilagus floridanus). Analysis of virion DNA of herpesvirus sylvilagus has revealed that the genome consists of one stretch of about 120 kilobase pairs of internal, unique DNA flanked by a variable number of 553-base-pair tandem repeats. The G + C content of the repetitive DNA is extremely high (83%), as determined by sequencing.
View Article and Find Full Text PDFPathogenesis of Herpesvirus sylvilagus infection in cottontail rabbits.
Am J Pathol
December 1988
University of Massachusetts Medical School, Department of Pediatrics, Worcester 01655.
Experimental infection with Herpesvirus sylvilagus produces clinical and histopathologic changes in its natural host, the cottontail rabbit (Sylvilagus floridanus), similar to those observed in humans acutely infected with Epstein-Barr virus (EBV). Twenty-seven seronegative cottontail rabbits were infected with Herpesvirus sylvilagus and all developed antibodies within 10 days. Neutralizing antibody was detected as early as 7 days after infection.
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