With consideration to the relatively high complication rate of internal fixation methods in the management of open fractures, 16-36% (17), the use of 'fixateur externe' or Hoffmann's apparatus is widely accepted as the best method of management. We do not have this valuable apparatus in our hospital due to the socioeconomic constraints typical of developing countries. We found a valuable improvisation in the use of Bohler's transfixation methods and even to the extent of achieving osteotaxis and ambulation. The management method is described with our positive experiences of its use in 28 cases of open fractures and other bone and joint afflictions. The advantages and disadvantages of the method are discussed. The method is recommended as a valuable substitute for the 'fixateur externe.'
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Neurospine
December 2024
Morgenstern Institute of Spine, Centro Médico Teknon, Barcelona, Spain.
This article aims to introduce a novel full-endoscopic anterior cervical discectomy and fusion (ACDF) procedure to treat cervical myelopathy. Adoption of endoscopic anterior cervical procedures has been lagging due to safety concerns and the necessity of placing an interbody cage. We have developed novel instrumentation and a modified percutaneous anterior cervical approach that allows a safe and reproducible full-endoscopic ACDF.
View Article and Find Full Text PDFCell Mol Life Sci
December 2024
Institute of Human Genetics, University Medical Center Göttingen, 37073, Göttingen, Germany.
Loss-of-function variants in ATP6V0A2, encoding the trans Golgi V-ATPase subunit V0a2, cause wrinkly skin syndrome (WSS), a connective tissue disorder with glycosylation defects and aberrant cortical neuron migration. We used knock-out (Atp6v0a2) and knock-in (Atp6v0a2) mice harboring the R755Q missense mutation selectively abolishing V0a2-mediated proton transport to investigate the WSS pathomechanism. Homozygous mutants from both strains displayed a reduction of growth, dermis thickness, and elastic fiber formation compatible with WSS.
View Article and Find Full Text PDFAnn Noninvasive Electrocardiol
January 2025
ECG Monitoring Research Lab, Department of Physiological Nursing, School of Nursing, University of California San Francisco, San Francisco, California, USA.
Biomolecules
October 2024
Institute for Anesthesiological Pathophysiology and Process Engineering, University Ulm, 89081 Ulm, Germany.
Early life stress (ELS) significantly increases the risk of chronic cardiovascular diseases and may cause neuroinflammation. This post hoc study, based on the material available from a previous study showing elevated "serum brain injury markers" in male control animals, examines the effect of sex and/or ELS on the cerebral and cardiac expression of the HS and oxytocin systems. Following approval by the Regional Council of Tübingen, a randomized controlled study was conducted on 12 sexually mature, uncastrated German Large White swine of both sexes.
View Article and Find Full Text PDFBiomedicines
November 2024
Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.
Background: Acute and chronic pre-traumatic cigarette smoke exposure increases morbidity and mortality after trauma and hemorrhage. In mice with a genetic deletion of the HS-producing enzyme cystathione-γ-lyase (CSE), providing exogenous HS using sodium thiosulfate (NaSO) improved organ function after chest trauma and hemorrhagic shock. Therefore, we evaluated the effect of NaSO during resuscitation from blunt chest trauma and hemorrhagic shock on CSE mice with pre-traumatic cigarette smoke (CS) exposure.
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