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Comparative glucocorticoid receptor agonism: In silico, in vitro, and in vivo and identification of potential biomarkers for synthetic glucocorticoid exposure.
Environ Toxicol Chem
January 2025
Department of Environmental Science, Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, TX, United States.
The glucocorticoid receptor (GR) is present in almost every vertebrate cell and is utilized in many biological processes. Despite an abundance of mammalian data, the structural conservation of the receptor and cross-species susceptibility, particularly for aquatic species, has not been well defined. Efforts to reduce, refine, and/or replace animal testing have increased, driving the impetus to advance development of new approach methodologies (NAMs).
View Article and Find Full Text PDFFatty acid carbon isotopes as tracers of trophic structure and contaminant biomagnification in Arctic marine food webs.
Sci Total Environ
January 2025
Department of Natural Resource Sciences, McGill University, Sainte-Anne-de-Bellevue, QC H9X 3V9, Canada. Electronic address:
Mercury (Hg) and persistent organic pollutant (POP) accumulation among species and biomagnification through food webs is typically assessed using stable isotopes of nitrogen (δN) and carbon (δC) in bulk (whole) tissues. Yet, bulk isotopic approaches have limitations, notably from the potential overlap of isotope values from different dietary sources and from spatial variation in source (baseline) signals. Here, we explore the potential of fatty acid carbon isotopes (FA δC) to (1) evaluate the trophic structure of a marine food web, (2) distinguish feeding patterns among four marine mammal consumers, (3) trace contaminant biomagnification through a food web, and (4) explain interspecific variation in contaminants among high-trophic position predators.
View Article and Find Full Text PDFLower Cadmium Bioavailability and Toxicity in Japonica Rice than in Indica Rice: Mechanisms and Health Implications.
Environ Sci Technol
January 2025
Institute of Soil and Water Resources and Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
Cadmium (Cd) is efficiently transferred from soil to food crops, notably rice. Research indicates that indica rice grains may accumulate more Cd than japonica cultivars; however, differences in Cd bioavailability (the fraction of ingested rice Cd absorbed into the systemic circulation) and toxicity remain unexplored, thus hindering a comprehensive understanding of exposure and health risks. To address this, a mouse bioassay was conducted to evaluate the relative bioavailability (RBA) of Cd in 35 samples each of japonica and indica rice, determining which type exhibits lower Cd bioavailability.
View Article and Find Full Text PDFResponses of zooplankton community to anthropogenic organic matters in representative lake in highly urbanized area: Taking lake Taihu as an example.
J Environ Manage
January 2025
State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, 810016, China.
Although terrestrial organic matter is known to sustain food chains, its impact on zooplankton communities in lakes within urbanized areas remains unclear. This study analyzed a comprehensive, decade-long dataset (1998-2007) that included COD, BOD, and monthly zooplankton records from Lake Taihu to assess the effects of anthropogenic organic matter. Significant spatial variations in COD and BOD were observed across different areas of Lake Taihu (p < 0.
View Article and Find Full Text PDFAssessment of dynamics of pathogenic environmental T4 and T9 genotypes isolated from three recreational lakes in Klang Valley, Malaysia over the HaCaT cell monolayer.
J Water Health
December 2024
Centre for Medical Laboratory Technology Studies, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam Campus, Selangor, Malaysia; Microbiome Health and Environment (MiHeaRT), Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia E-mail:
Free-living amoebae of the genus are causative agents of keratitis and amoebic encephalitis. They are widely found in various ecological environments. Therefore, the present study brings results that can help to better understand the genotypes of the environmental isolates and their pathogenicity.
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