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Multi-dimensional bio mass cytometry: simultaneous analysis of cytoplasmic proteins and metabolites on single cells.
Chem Sci
January 2025
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University Beijing 100871 China
Single-cell multi-dimensional analysis enables more profound biological insight, providing a comprehensive understanding of cell physiological processes. Due to limited cellular contents, the lack of protein and metabolite amplification ability, and the complex cytoplasmic environment, the simultaneous analysis of intracellular proteins and metabolites remains challenging. Herein, we proposed a multi-dimensional bio mass cytometry platform characterized by protein signal conversion and amplification through an orthogonal exogenous enzymatic reaction.
View Article and Find Full Text PDFIrisin reshapes bone metabolic homeostasis to delay age-related osteoporosis by regulating the multipotent differentiation of BMSCs via Wnt pathway.
Front Mol Biosci
January 2025
The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, China.
Introduction: Bone aging is linked to changes in the lineage differentiation of bone marrow stem cells (BMSCs), which show a heightened tendency to differentiate into adipocytes instead of osteoblasts. The therapeutic potential of irisin in addressing age-related diseases has garnered significant attention. More significantly, irisin has the capacity to enhance bone mass recovery and sustain overall bone health.
View Article and Find Full Text PDFQuantitative assessment of early changes in myocardial extracellular volume during postoperative adjuvant chemotherapy in patients with breast cancer via dual-layer spectral detector computed tomography: a cohort study.
Quant Imaging Med Surg
January 2025
Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China.
Background: The major of anticancer therapies induce a wide spectrum of cardiotoxic effects. Early identification of anticancer treatment-associated cardiotoxicity is critical to informing decisions on subsequent interventions. Myocardial extracellular volume (ECV) has been proposed as a useful parameter for quantifying the early cardiotoxicity of cancer-related treatment.
View Article and Find Full Text PDFAdvanced Quantitative Phase Microscopy Achieved with Spatial Multiplexing and a Metasurface.
Nano Lett
January 2025
Department of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Quantitative optical phase information provides an alternative method to observe biomedical properties, where conventional phase imaging fails. Phase retrieval typically requires multiple intensity measurements and iterative computations to ensure uniqueness and robustness against detection noise. To increase the measurement speed, we propose a single-shot quantitative phase imaging method with metasurface optics that can be conveniently integrated into conventional imaging systems with minimal modification.
View Article and Find Full Text PDFTCF19 Enhances Glioma Cell Proliferation via Modulating the Β-Catenin Signaling Pathway through Accelerating DHX32 Transcription.
Curr Cancer Drug Targets
January 2025
Department of Neurosurgery, the First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, 277 Yanta West Road, Xi'an, 710061, China.
Background: Transcription factor 19 (TCF19) is considered a crucial transcription factor and acts as an oncogene in a few cancers. Nevertheless, the effect and mechanism of TCF19 on glioma remain unknown.
Objective: This research aimed to explore the function of TCF19 on glioma progression and clarify the potential mechanism.
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