Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF01889163 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The glucagon-receptor antagonist MK-3577 reduces glucagon-stimulated plasma glucose and insulin concentrations in metabolically healthy overweight cats.
Domest Anim Endocrinol
October 2024
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon Tharp St., Columbus, OH 43210, USA; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 SW 16th Ave. Gainesville, FL 32608, USA. Electronic address:
The role of glucagon disturbances in diabetes mellitus is increasingly recognized and, hence, glucagon antagonism might aid in treatment of hyperglycemia and other metabolic disturbances. The aim of this study was to assess the pharmacokinetics of the glucagon receptor antagonist MK-3577 and its effect on plasma glucose, insulin, and glucagon concentrations in healthy cats. In a cross-over placebo-controlled study, 5 purpose-bred cats were treated with either Placebo, MK-3577 (1 mg/kg), or MK-3577 (3 mg/kg).
View Article and Find Full Text PDFHigh-energy pacing inhibits slow-wave dysrhythmias in the small intestine.
Am J Physiol Gastrointest Liver Physiol
June 2024
Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
The motility of the gastrointestinal tract is coordinated in part by rhythmic slow waves, and disrupted slow-wave patterns are linked to functional motility disorders. At present, there are no treatment strategies that primarily target slow-wave activity. This study assessed the use of pacing to suppress glucagon-induced slow-wave dysrhythmias in the small intestine.
View Article and Find Full Text PDFTW68, cryptochromes stabilizer, regulates fasting blood glucose levels in diabetic ob/ob and high fat-diet-induced obese mice.
Biochem Pharmacol
December 2023
Department of Molecular Biology and Genetics, Koc University, Rumelifeneri Yolu, Istanbul, Türkiye; Department of Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Istanbul, Türkiye. Electronic address:
Cryptochromes (CRYs), transcriptional repressors of the circadian clock in mammals, inhibit cAMP production when glucagon activates G-protein coupled receptors. Therefore, molecules that modulate CRYs have the potential to regulate gluconeogenesis. In this study, we discovered a new molecule called TW68 that interacts with the primary pockets of mammalian CRY1/2, leading to reduced ubiquitination levels and increased stability.
View Article and Find Full Text PDFIntestinal Electrical Stimulation Synchronized With Intestinal Slow Wave Ameliorates Glucagon-Induced Hyperglycemia in Rats.
Neuromodulation
February 2024
Division of Gastroenterology and Hepatology, University of Michigan School of Medicine, Ann Arbor, MI, USA. Electronic address:
Background: Synchronized intestinal electrical stimulation (SIES), in which intestinal electrical stimulation (IES) is delivered in synchronization with the intrinsic slow wave of small intestine, was previously reported to be more potent in accelerating small intestine transit than IES delivered at fixed frequency and phase. We hypothesized that SIES is more potent in suppressing postprandial blood glucose by enhancing the release of glucagon-like peptide-1 (GLP-1) and insulin.
Materials And Methods: Rats underwent long-term implant of two pairs of electrodes at the duodenum for IES and SIES, respectively.
Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators.
Biochem J
June 2022
Université Catholique de Louvain (UCLouvain) and de Duve Institute (DDUV), Avenue Hippocrate 75, 1200 Brussels, Belgium.
Pharmacological AMPK activation represents an attractive approach for the treatment of type 2 diabetes (T2D). AMPK activation increases skeletal muscle glucose uptake, but there is controversy as to whether AMPK activation also inhibits hepatic glucose production (HGP) and pharmacological AMPK activators can have off-target effects that contribute to their anti-diabetic properties. The main aim was to investigate the effects of 991 and other direct AMPK activators on HGP and determine whether the observed effects were AMPK-dependent.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!