AI Article Synopsis
- Multiple myeloma (MM) is a rare plasma cell disorder that can sometimes affect the skin, with only 1.14% of patients showing such involvement.
- The study analyzed 14 patients with skin involvement, finding that those affected had a significantly lower overall survival rate compared to those without skin involvement, averaging 28 months versus 57 months.
- Key findings indicated that specific skin features like erythematous nodules, multiple lesions, and lack of a grenz zone were linked to worse survival outcomes, although the study's small sample size and retrospective nature limit its conclusions.
Article Abstract
Background: Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the presence of a clonal proliferation of tumor cells. Cutaneous involvement of MM is very rare and remains poorly understood.
Objective: The aim of this study was to examine the clinical and histopathologic characteristics of cutaneous involvement in MM and identify factors associated with overall survival of MM with cutaneous involvement.
Methods: The medical records of 1228 patients with MM were retrieved and analyzed. Of those patients, 14 with cutaneous involvement of MM (1.14%) were further evaluated for their clinical and histopathologic findings.
Results: Patients with cutaneous involvement showed significantly reduced overall survival compared with those without cutaneous involvement (median, 28 vs. 57 months; hazard ratio, 1.929; 95% confidence interval, 1.030-3.613). In subgroup analyses of patients with MM with cutaneous involvement, erythematous nodules (P = .004), multiple cutaneous lesions (P = .002), and absence of a grenz zone (P = .004) were clinicopathologic features associated with reduced overall survival after Bonferroni correction.
Limitations: The retrospective design and the small sample size are the limitations.
Conclusion: Cutaneous involvement accounted for about 1.14% of patients with MM and was associated with reduced overall survival.
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| http://dx.doi.org/10.1016/j.jaad.2017.08.054 | DOI Listing |
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