Melatonin counteracts tumor occurrence and tumor cell progression in several cancer types and . It acts predominantly through its melatonin receptor type 1A (MTNR1A), and genetic variations of affect the susceptibility several diseases and cancer. The purpose of this study was to explore the effect of gene polymorphisms on the susceptibility to and clinicopathological characteristics of urothelial cell carcinoma (UCC). We recruited 272 patients with UCC and 272 normal controls to analyze three common single-nucleotide polymorphisms (SNPs) (rs2119882, rs13140012, and rs6553010) of related to cancer risk and clinicopathological relevance according to a TaqMan-based real-time polymerase chain reaction (PCR). We found that these three SNPs of were not associated with UCC susceptibility. However, patients with UCC who had at least one G allele of rs6553010 (in intron 1) were at higher risk (1.768-fold, 95% confidence interval: 1.068~1.849) of developing an invasive stage ( < 0.026), compared to those patients with AA homozygotes. In conclusion, polymorphic genotypes of rs6553010 of might contribute to the ability to predict aggressive phenotypes of UCC. This is the first study to provide insights into risk factors associated with intronic variants in the clinicopathologic development of UCC in Taiwan.
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| http://dx.doi.org/10.7150/ijms.20629 | DOI Listing |
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