Objective: To study influence of abstinence period on the live-birth rate after assisted reproductive technology (ART).
Design: Retrospective cohort study.
Setting: Reproductive medicine unit, university-level hospital.
Patient(s): A total 1,030 ART cycles evaluated from 2011 to 2015.
Intervention(s): Group I, abstinence period 2-7 days, and group II, abstinence period >7 days, were compared. Two subgroups Ia (2-4 days) and Ib (5-7 days) were also compared with group II.
Main Outcome Measure(s): Primary outcome was live birth per ET. Secondary outcomes included implantation, clinical pregnancy, and miscarriage rates.
Result(s): The live-birth rate (34.1 % vs. 24.1%; odds ratio [OR], 1.6; 95% confidence interval [CI], 1.1-2.4), clinical pregnancy rate (44.4 % vs. 32.7%; OR, 1.6; 95% CI, 1.1-2.3), and implantation rate (26.4% vs. 18.2%) were significantly higher in group I compared with group II. Other secondary outcomes of fertilization rate and miscarriage rate did not differ between groups I and II. The adjusted odds ratio (aOR) for live birth (aOR, 1.6; 95% CI, 1.1-2.5) and clinical pregnancy rates (aOR, 1.7; 95% CI, 1.2-2.5) were significantly higher for group I compared with group II. The live-birth rate was significantly higher in group Ia (36.1% vs. 24.1%) compared with group II.
Conclusion(s): An abstinence period of more than 7 days may impact ART outcomes adversely when compared with an abstinence period of 2-7 days.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.fertnstert.2017.08.034 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Associations of the Korean patient placement criteria matching among individuals with alcohol-related problems with treatment completion and abstinence: an observational study.
Addict Sci Clin Pract
December 2024
Department of Psychiatry, Hanyang University Hospital, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea.
Background: The American Society of Addiction Medicine Patient Placement Criteria (ASAM PPC) are guidelines for matching addiction patients to an optimal level of care (LOC). South Korea lacked a systematic approach to assigning alcohol use disorder patients to suitable treatment. To address this, Park et al.
View Article and Find Full Text PDFEpac2-mediated synaptic insertion of Ca-permeable AMPARs in the nucleus accumbens contributes to incubation of cocaine craving.
Neuropsychopharmacology
December 2024
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.
The accumulation of GluA2-lacking Ca-permeable AMPARs (CP-AMPARs) in the medium spiny neurons (MSNs) of the nucleus accumbens (NAc) is required for the expression of incubation of cocaine craving. The exchange protein directly activated by cAMP (Epac) is an intracellular effector of cAMP and a guanine nucleotide exchange factor for the small GTPase Rap1. Epac2 has been implicated in the trafficking of AMPA receptors at central synapses.
View Article and Find Full Text PDFLisdexamfetamine in the treatment of methamphetamine dependence: A randomised, placebo-controlled trial.
Addiction
December 2024
Drug and Alcohol Clinical Research and Improvement Network, NSW Health, Sydney, Australia.
Aims: This study tested the efficacy and safety of a 12-week course of lisdexamfetamine in reducing methamphetamine use, an outcome which is associated with improvements in health and wellbeing, in people dependent on methamphetamine.
Design, Setting And Participants: This study was a randomised double-blind placebo-controlled trial conducted in six specialist outpatient clinics in Adelaide, Melbourne, Newcastle and Sydney, Australia (2018-2021). Participants were164 adults with methamphetamine dependence, reporting at least 14 use days out of the previous 28 days (62% male, 38% female, < 1% other; mean age 39 years).
A survey of quit vaping strategies and relapse triggers for maintaining youth and young adult vaping abstinence in Canada.
J Addict Dis
December 2024
Department of Psychology, Saint Mary's University, Halifax, Canada.
Objectives: To examine whether various quit strategies and relapse triggers are associated with maintenance period in a sample of people who quit vaping.
Method: Young Canadians who used to vape ( = 772) completed an online survey on maintenance period, quit strategies, and relapse triggers. Logistic regression was employed to variables associated with maintenance period.
Roles of metabotropic signaling of nicotine receptors in the development and maintenance of nicotine reward through regulation of dopamine D receptor expression.
J Neurochem
January 2025
College of Pharmacy, Chonnam National University, Gwangju, Republic of Korea.
The α4β2 nicotinic acetylcholine receptor (nAChR), an ionophore, has been suggested to signal through metabotropic pathways and interact with other receptor families, such as dopamine receptors. In this study, the interaction between α4β2 nAChR and dopamine receptors was investigated through in vivo and in vitro studies. Nicotine exposure in adolescent rats is known to induce a sustained increase in nicotine's rewarding effects which was assessed by conditioned place preference (CPP) assay.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!